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題 名 | Antioxidant and Antihypertensive Activities of Acteoside and Its Analogs=洋丁香苷及其結構類似物之抗氧化與抗高血壓活性評估 |
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作 者 | 陳兆祥; 林音秀; 簡美英; 侯文琪; 胡淼琳; | 書刊名 | Botanical Studies |
卷 期 | 53:4 2012.10[民101.10] |
頁 次 | 頁421-429 |
分類號 | 414.51 |
關鍵詞 | 洋丁香苷; 抗高血壓活性; 血管收縮素轉化酶; 抗氧化; 溶血; Acteoside; Antihypertensive activity; Angiotensin converting enzyme; ACE; Antioxidant; Hemolysis; |
語 文 | 英文(English) |
中文摘要 | 洋丁香苷(Acteoside, Act),是許多植物或中草藥中的活性成分。本試驗利用洋丁香苷及兩種結構類似物,異洋丁香苷(isoacteoside, Isoact)與6-乙酸基洋丁香苷(6-O-acetylacteoside, 6-O-acetylact),進行抗氧化、抗血管收縮素轉化酶、抗溶血體外試驗及以自發性高血壓鼠進行抗高血壓之動物試驗。結果顯示,三種試驗樣品皆能有效清除DPPH自由基與超氧自由基。因為異洋丁香苷與6-乙醯洋丁香苷有類似清除自由基活性,因此後面試驗只以洋丁香苷與異洋丁香苷進行比較。兩者皆具有抑制黃嘌呤氧化酶與血管收縮素轉化酶活性;在抑制2,2'-azo-bis(2-amidinopropane)dihydrochloride誘發溶血試驗上,洋丁香苷效果優於異洋丁香苷。以自發性高血壓鼠進行抗高血壓之動物試驗,洋丁香苷與異洋丁香苷分別以10 mg/Kg劑量單一餵食一次觀察24小時血壓變化。結果顯示,在此劑量上只有洋丁香苷具有明顯調降高血壓鼠收縮壓與舒張壓活性。這些結果顯示,含有洋丁香苷的中草藥可能可以做為抗氧化與血壓調節之保健食品。 |
英文摘要 | Acteoside (Act), a phenylethanoid glycoside, is an active compound in several plants and traditional herbal medicines. Act along with its structural isomer, isoacteoside (Isoact), and an analog, 6-O-acetylacteoside (6-O-acetylact), were used in the study to investigate the antioxidant, anti-angiotensin-converting enzyme (ACE), and hemolysis inhibitory activities in vitro and antihypertensive activity against spontaneously hypertensive rats (SHR) in vivo. We showed that Act, Isoact, and 6-O-acetylact effectively scavenged 1,1-diphenyl- 2-picryl-hydrazyl radicals (with IC50 at 11.4, 9.48, and 9.55 μM, respectively) and superoxide radicals (with IC50 at 66.0, 38.5, and 39.1 μM, respectively). As Isoact and 6-O-acetylact had similar radical-scavenging activities, only Act and Isoact were used for following studies. Both Act and Isoact inhibited xanthine oxidase activity with IC50 at 53.3 and 62.2 μM, respectively. Both Act and Isoact also significantly inhibited ACE activity and the hemolysis induced by 2,2'-azo-bis(2-amidinopropane)dihydrochloride, but the effects of Act were stronger than Isoact. We then orally administered a single dose of Act or Isoact (10 mg/Kg body weight) to SHR and measured the changes of systolic blood pressure (SBP) and diastolic blood pressure (DBP) over 24 h. Act, but not Isoact, showed antihypertensive activity in lowering SBP and DBP. The results suggest the potential usefulness of Act as a health food product for antioxidant protection and blood pressure regulation. |
本系統中英文摘要資訊取自各篇刊載內容。