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題 名 | Strong Association of Antiepithelial Cell Antibodies with HLA-DR3 or DR7 Phenotype in Patients with Recurrent Oral Ulcers=抗上皮細胞抗體和國人復發性口腔潰瘍患者之人類白血球抗原DR3或DR7遺傳表型高度相關 |
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作 者 | 孫安迪; 謝榮峰; 劉步遠; 王拯宗; 吳英俊; 江俊斌; | 書刊名 | 臺灣醫學會雜誌 |
卷 期 | 99:4 2000.04[民89.04] |
頁 次 | 頁290-294 |
分類號 | 416.94 |
關鍵詞 | 抗上皮細胞抗體; 復發性口腔潰瘍; 白血球抗原DR3; 白血球抗原DR7; 中國; Antiepithelial cell antibodies; HLA-DR antigens; HLA-DQ antigens; Chinese; Recurrent oral ulcers; |
語 文 | 英文(English) |
英文摘要 | Background: Previous studies showed that antiepithelial cell antibodies (anti-ECA) were present in 71% (15/21) of patients with recurrent oral ulcers (ROU) and that there was a strong association of human leukoctye antigen (HLA)-DRw9 with ROU in Chinese patients. In this study, we assessed anti-ECA in a larger group of Chinese patients with ROU (n = 88) in order to further investigate the association of anti-ECA with HLA-DR and -DQ antigens. Methods: The anti-ECA in the sera of ROU patients were detected by an indirect immunofluorescence technique with rat esophagus as the substrate, and the HLA-DR and -DQ antigens in ROU patients were typed by a standard microcytotoxicity assay using Terasaki's oriental tray. Results: The rate of anti-ECA positivity was significantly higher (p < 0.0001) in ROU patients (68%) than in healthy control subjects (0%). Furthermore, the rate of anti- ECA positivity in patients with major or minor oral ulcers (72%) was significantly higher (29%) than that in patients with herpetiform ulcers (p < 0.05). There was a significant increase in the frequency of DR3 or DR7 antigen expression (p < 0.0001, p c [p corrected] < 0.001, relative risk [RR] = 4.3, etiologic fraction = 0.41) in anti- ECA-positive ROU patients compared with the corresponding frequencies in healthy control subjects. There was also a significant increase in the frequency of DR7 or DRw9 antigen expression (p < 0.005, p c < 0.05, RR = 4.7, etiologic fraction = 0.45) compared to healthy controls. Conclusions: Because only DR3 or DR7 antigen occurred more frequently in anti- ECA-positive than in anti-ECA-negative ROU patients (p < 0.0007, p c < 0.05, RR = 19.6, etiologic fraction = 0.51), we concluded that the gene coding for DR3 or DR7 antigen may contribute to the presence of anti-ECA in Chinese patients with ROU. |
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