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題名 | The Relation of White Blood Cell Count and Atherogenic Index Ratio of LDL-Cholesterol to HDL-Cholesterol in Taiwan School Children=學齡兒童白血球數與致動脈硬化指數之關係 |
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作者 | 劉秋松; 林正介; 李采娟; | 書刊名 | 臺灣兒科醫學會雜誌 |
卷期 | 40:5 民88.09-10 |
頁次 | 頁319-324+360 |
分類號 | 415.6 |
關鍵詞 | 致動脈硬化指數; 兒童; 白血球數; Atherogenic index; Children; White blood cell count; |
語文 | 英文(English) |
中文摘要 | 流行病學資料顯示白血球數升高是成年人心血管疾病的危險因子。為瞭解白血球 數與兒童動脈粥狀硬化傾向的關係,從1996年2月至6月在臺中進行一橫斷式研究。從母群 體47800位學生中,經由二階段抽樣法選出4520位學生當研究樣本,最後符合分析條件者有 3818位。低密度膽固醇與高密度膽固醇的比值定義為動脈硬化指數。結果顯示:動脈硬化指 數高者比低者有較高的平均白血球數(6.82x109 cells/L比6.58 x 109 cells/L,p<0.001)。 經由多變項邏輯迥歸分析;在控制年齡、性別及血脂肪濃度等因素下,在肥胖的兒童中,白血 球數過高(≧7.8x109 cells/L)是致動脈硬化性的危險指標(Odds ratio:1.70,95%信賴區 間:1.20-2.41)。其它與致動派硬化性有關的因子包括性別、肥胖、年齡及血脂肪濃度。 |
英文摘要 | White blood cell (WBC) count is an independent coronary risk factor in adults. To clarify the relation of WBC count and atherogenesity in children, we conducted a cross-sectional study in Taiwan from February to June 1996. A total of 3818 subjects were eligible in the final analyses. The ratio of low to high density lipoprotein cholesterol was calculated as atherogenic index. The 75th percentile of atherogenic index was calculated and used as cut-off point for high and low levels. The mean WBC count in children with high atherogenic index (6.82×109 cells/L) was significantly (p<0.001) higher than those with low atherogenic index (6.58×109 cells/L). By multiple logistic regression analysis, higher WBC count (≧7.8×109 cells/L) was found to be an independent risk indicator of atherogenesity (odds ratio: 1.70,95% confidence interval: 1.20-2.41) among obese children. Other significant factors associated with atherogenesity were gender, obesity, age, triglyceride and total cholesterol level. Our results indicate that obese children with higher WBC count have higher atherogenic index. |
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