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題 名 | Correlations of Serum Lipids, Uric Acid, and Albumin among Mothers, Offspring, and Siblings in Taipei, Taiwan=母子世代血液中四種脂質、尿酸及白蛋白之相關性研究 |
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作 者 | 鄭心嫻; 楊淑惠; 陳成; 江明樹; | 書刊名 | 臺灣兒科醫學會雜誌 |
卷 期 | 40:4 民88.07-08 |
頁 次 | 頁225-232+287 |
分類號 | 414.7 |
關鍵詞 | 血脂質; 母親; 幼童; 遺傳率; 臺北; Serum lipids; Mother; Offspring; Heritability; Taipei; |
語 文 | 英文(English) |
中文摘要 | 本研究目的主要探討3至7歲208位受試幼童(Y)、與111位母親(X)及57位同 胞(Z)血液中三酸甘油酯(triglyceride)、總膽固醇(total cholesterol)、高密度脂蛋白膽 固醇(HDL-cholesterol)、低密度脂蛋白膽固醇(LDL-cholesterol)、尿酸(uric acid)、白 蛋白(albumin)、等六項。分別進行相關顯著性測驗、親裔迴歸分析及顯著性測驗、駢對-t 值(paired-comparison)、迴歸係數、(regression coeff., bop)、遺傳率(heritability, h □)測驗。結果顯示幼童與母親之六個性狀迴歸係數(b□)中除三酸甘油酯為顯著(p<0.05) 外,其餘均為極顯著(p<0.01)。而同胞與母親之迴歸係數(b□)極顯著者(p<0.01)分別為總 膽固醇、低密度脂蛋白膽固醇及白蛋白,而尿酸為顯著(p<0.05)。在受測幼童及其同胞除總 膽固醇為顯著(p<0.05),其餘均為極顯著(p<0.01),此結果顯示可能是由遺傳因子所控制。 因遺傳率(h□)分別高達0.75-1.0、0.77-1.0、0.96-1.0及0.48-0.82。本次研究發現,臺 北幼童血脂質與其母親血脂質顯著相關,可能是由遺傳因子所控制。 |
英文摘要 | The purpose of this study was to investigate the correlations of serum lipids, uric acid, and albumin, among mothers (n=111), offspring (n=208), and siblings (n=57) in Taipei, Taiwan. Analytical items included serum triglyceride, serum total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, uric acid, and albumin. Statistical analysis was performed according to the SAS UNIVARIATE procedure; while regression coefficient, parent-offspring regressions, paired-comparison and heritability were estimated. These results show higher heritabilities of four types of serum lipids, uric acid and albumin between mothers and testers (b□) or siblings (b□) by parent-offspring regression analysis. Regression coefficients (b□) of six characters were significantly different (p < 0.05-0.01). Regression coefficients (b□) for total cholesterol, low-density lipoprotein cholesterol, uric acid, and albumin were significantly different (p < 0.05 - 0.01), showing the result of genetic control, because their heritabilities were very high at 0.75-1.0, 0.77-1.0, 0.96-1.0, and 0.48-0.82, respectively. This study disclosed that the serum lipids of children in Taipei, Taiwan were significantly correlated with that of parents, which may be attributed to the result of genetic control. |
本系統中英文摘要資訊取自各篇刊載內容。