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頁籤選單縮合
題名 | 不同類型溝通障礙兒在腦部胼胝體面積差異之初報=Morphometric Study of the Corpus Callosum in Young Children with Different Types of Communication Disorders |
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作者 | 范心慧; 陳震宇; 吳文超; 王新臺; 黃朝慶; 高純珠; Fan, Shin-hui; Chen, Cheng-yu; Wu, Wen-chau; Wang, Shan-tair; Huang, Chao-ching; Kao, Chun-chu; |
期刊 | 慈濟醫學 |
出版日期 | 19990900 |
卷期 | 11:3 1999.09[民88.09] |
頁次 | 頁247-253 |
分類號 | 417.5847 |
語文 | chi |
關鍵詞 | 語言發展遲緩; 自閉症; 智能障礙; 胼胝體; 磁振造影; Developmental language disorder; Autistic spectrum disorder; Mental retardation; Corpus callosum; MRI; |
中文摘要 | 目的:連接左右大腦半球的胼胝體在訊息的傳遞與形成上具重要性,且影響個體 認知功能之發展,本研究將探討胼胝體面積在不同類型之溝通障礙兒之間的差異。病人及方 法:研究對象是臨床主訴為語言發展問題或溝通障礙之幼兒,據其臨床診斷、語言發展、認 知功能、行為調查等資料,分為發展性語言遲緩、智能障礙及自閉症三組,其接受磁振造影 檢查之平均年齡分別為(平均值±標準差): 語言遲緩組 39.5 ± 11.0 個月、 自閉症組 30.6 ± 8.1 個月、智能障礙組 36.3 ± 11.8 個月,年齡範圍為 18-57 個月, 三組之磁 振造影年齡未達統計顯著差異, 可進行比較,而追蹤評估之年齡範圍則在 53-60 個月之間 ,研究運用磁振造影進行胼胝體之量測,以探討三組兒童其胼胝體發育的情形是否有所不同 。結果:智能障礙組在胼胝體總面積及各部位面積皆為最小,三組兒童在胼胝體體部末端之 面積達統計之顯著差異( p=0.01 ), 且主要差異在智能障礙與語言發展遲緩組之間( p<0.05 ),顯示胼胝體之發育情形在三組之間有所不同。 結論:胼胝體體部末端與幼兒語 言及非語言之認知發展有關,本研究目前持續增加個案人數,並加入學齡兒童之個案,以進 行比較及進一步資料分析。 |
英文摘要 | Objective: The corpus callosum plays an important role in the development of human cognition, verbal as well as non-verbal. Developmental language disorder (DLD) , autistic spectrum disorder (ASD) , and mental retardation (MR) are the common causes of communication disorders in children. This study tested the hypothesis that there are differences in the area of the corpus callosum and its subregions in young children with DLD, ASD and MR. Patients and Methods: Thirty-three patients with verbal intelligence quotients below 70, were included in the study. There were 11 patients in each study roup. The mean ages (± SD ) in the DLD (39.5 ± 11.0 months), ASD (30.6 ± 8.1 months ) and MR (36.3 ± 11.8 months) groups at MRI examination were comparable. A semi-automated, computer-assisted procedure was used to measure the total brain areas, and the total area of the corpus callosum and its five subregions on the midsagittal T1-weighted magnetic resonance imaging. Results: The total brain areas (Mean ± SD, cm �� ) in the DLD, ASD and MR groups were 127.6 ± 17.8, 127.5 ± 13.7, 118.6 ± 20.1, respectively. After standardization with respect to total brain area, there was no significant difference in the total corpus callosum area (cm �� ) between the three groups (4.24 ± 1.38, 3.55 ± 0.67, and 2.83 ± 1.63 for DLD, ASD, and MR, respectively), although the MR group had the smallest total area of corpus callosum among the three groups. After comparing the 5 different subregions of the corpus callosum among the three groups, a significant difference was observed only in the posterior body of the corpus callosum (p=0.01), with the smallest area in the MR group. A significant difference in the posterior body of the corpus callosum was observed only between the DLD and MR groups (P<0.05). Conclusions: we found that there are differences in the subregions of the corpus callosum, especially in its posterior body, between children with DLD, ASD and MR. This preliminary study suggests that a decrement in the development of the corpus callosum occurs more often in young children with mental retardation than in children with communication disorders. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。