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題名 | Effect of Weight Reduction on Serum Uric Acid, Urinary Excretion of Uric Acid and Insulin Resistance in Obese Individuals=肥胖者體重減輕對血清尿酸、尿酸排泄以及胰島素抗性的影響 |
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作者 | 金惠民; 許惠恆; 蘇秀悅; | 書刊名 | 中華民國營養學會雜誌 |
卷期 | 24:2 1999.05[民88.05] |
頁次 | 頁167-177 |
分類號 | 415.599 |
關鍵詞 | 胰島素抗性; 高尿酸血症; 肥胖; 體重減輕; Insulin resistance; Hyperuricemia; Obesity; Weight loss; |
語文 | 英文(English) |
中文摘要 | 肥胖者常出現高尿酸血症,它可能與高胰島素血症產生的胰島素抗性有關。本研究即在於探究肥胖者血清中尿酸值與胰島素抗性,以及其他相關生化值的相關性;同時觀察肥胖者在減輕了10%體重後,血清尿酸及尿酸排泄量改變的情形。共計46位肥胖者參加本研究,BMI平均值為29.9 ± 0.53 kg/m�插A其胰島素媒介的葡萄糖量(定義為胰島素抑制實驗中,穩定狀態下的血漿葡萄糖濃度)與血清尿酸值有明顯的相關性(r=0.524; P<0.001)而血液尿酸值與尿液中尿酸清除能力則成負相關(r=-0.45; P<0.001)。對於順利減輕10%體重的21位肥胖者,他們的血清尿酸值在減重前後明顯下降(0.34 ± 0.02 mmol/L vs. 0.30 ± 0.01 mmol/L; P<0.002),胰島素抗性改善(SSPG: 13.58 ± 0.53 mmol/L vs.9.67 ± 0.72 mmol/L; P<0.0001),但是尿液中尿酸的清除率(CUA/CCr)卻並無明顯改變。我們推論:肥胖者血清尿酸值與其胰島素抗性具有相關性,而肥胖者體重減輕10%即可使血清尿酸值明顯降低,並有效改善胰島素抗性。 |
英文摘要 | Hyperuricemia has been found to exist in obese individuals. It has been shown that subjects with hyperuricemia are characterized by insulin resistance and hyperinsulinemia. The purpose of this study was to investigate the relationship of serum uric acid concentration, insulin resistance and the associated metabolic variations in a group of obese subjects. We also studied the effect of losing 10% of initial weight on serum and urinary excretion of uric acid. Forty six obese subjects with mean body mass index 29.9 ± 0.53 kg/m�� were studied at Tri-Service General Hospital. The resistance to insulin-mediated glucose uptake (as defined by SSPG concentrations during insulin suppression test) and serum uric acid concentration were highly correlated (r=0.524; P<0.001). Serum uric acid concentrations were negatively associated with urinary clearance of uric acid divided by clearance of creatinine (CUA/CCr) (r=-0.45; P<0.001). Mean value of serum uric acid in 21 subjects who lost 10% of initial weight decreased significantly (0.34 ± 0.02 mmol/L vs. 0.30 ± 0.01 mmol/L; P<0.002), insulin resistance improved (SSPG: 13.58 ± 0.53 mmol/L vs. 9.67 ± 0.72 mmol/L, P<0.0001) while values of urinary CUA/CCr ratio remained unchanged. We concluded that serum uric acid levels were related to degree of insulin resistance in a group of Chinese obese subjects. Weight loss for 10% of initial weight led to decrease of serum uric acid levels and improvement of insulin resistance. |
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