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- Insulin Resistance in Obese Adolescents
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頁籤選單縮合
題名 | Insulin Resistance in Obese Adolescents=肥胖青少年的胰島素抗性 |
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作者 | 李欣蓉; 黃琪鈺; 李宏昌; 陳銘仁; 羅福松; 林照旭; 王安美; 施並富; 李燕晉; Li, Hsing-jung; Huang, Chi-yu; Lee, Hung-chang; Chen, Ming-ren; Lo, Fu-sung; Lin, Chao-hsu; Wang, An-mei; Shih, Bing-fu; Lee, Yann-jinn; |
期刊 | 臺灣兒科醫學會雜誌 |
出版日期 | 20050300、20050400 |
卷期 | 46:2 民94.03-04 |
頁次 | 頁61-66+114 |
分類號 | 415.599 |
語文 | eng |
關鍵詞 | 肥胖; 青少年; 胰島素抗性; 黑棘皮症; Obesity; Adolescents; Insulin resistance; Acanthosis nigricans; |
英文摘要 | The prevalence of obesity in adolescents is increasing rapidly. Obesity is associated with insulin resistance, which increases the risk for type 2 diabetes. We investigated insulin resistance in obese adolescents and its relationship to acanthosis nigricans. Height, weight and body mass index (BMI) were measured and each was expressed as a standard deviation score (SDS) based on national growth standards. Insulin resistance was estimated by using the homeostasis model assessment (HOMA-IR) score, calculated as fasting insulin (μU/mL)×fasting glucose (mmol/L)/22.5. Obese adolescents had significantly greater weight-SDS, BMI-SDS, fasting insulin levels, and HOMA-IR than did controls with normal weight. Acanthosis nigricans was present in 58.4% of obese adolescents. Fasting insulin levels and BMI-SDS were positively correlated with the degree of acanthosis nigricans (r=0.383, P<0.0001 and r=0.164, P<0.05, respectively). On multiple regression analysis, HOMA-IR and BMI-SDS explained 16.8% of the degree of acanthosis nigricans (P<0.0001). Acanthosis nigricans thus may be a marker of insulin resistance and should be carefully looked for in obese adolescents. |
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