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題 名 | Acute Inductive Effects on Oncogenic Proline-Directed Protein Kinase F坧 /GSK-3α in NIH 3T3 Cells by Ethanol and Cadmium=乙醇與鎘離子逆境快速誘導致癌性脯胺酸引導蛋白質激酶F坧於NIH 3T3細胞內的表現 |
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作 者 | 許晉銓; 徐治平; 楊銓慶; 楊孝德; | 書刊名 | Proceedings of the National Science Council : Part B, Life Science |
卷 期 | 22:2 1998.04[民87.04] |
頁 次 | 頁68-75 |
分類號 | 361.1925 |
關鍵詞 | 乙醇; 鎘離子逆境; 致癌性脯胺酸; 蛋白質激酶; PDPK F坧/GSK-3α; Ethanol; Cadmium; |
語 文 | 英文(English) |
中文摘要 | 當NIH 3T3細胞受375mM的乙醇處理後,致癌性的脯胺酸引導蛋白質激□FA的蛋 白質表現量與活性,會隨著作用時間於二十分鐘後快速增加三倍。如果只用100mM濃度的乙 醇處理,則可於四十分鐘後達到最大的誘導效果。相同地,當IH 3T3細胞處於100μM濃度 的鎘離子逆境時,於兩小時後使致癌性的脯胺酸引導蛋白質激□FA的蛋白質表現量與活性 增加2.5倍。加果只用50μM濃度的鎘離子逆境處理,則可於三小時後達到最大的誘導效果。 由這些結果可以證明,蛋白質激□FA並非如同之前所設想的:是一個恆定表現,且受致癌因 子所抑制的蛋白質激□。綜合前一篇脯胺酸引導蛋白質激□FA可受熱逆境而增加活性的報 告,此篇的報告更可進一步證明:脯胺酸引導的蛋白質激□FA是個標準的、可受細胞逆境而 活化的蛋白質激□,並且可受熱逆境、乙醇與鎘離子逆境的作用而早期的快速表現。 |
英文摘要 | Exposure of NIH 3T3 cells to 375 mM ethanol at 37℃ for 20 min could induce a rapid increase in the protein level and cellular activity of oncogenic proline-directed protein kinase FA/glycogen synthase kinase-3α (PDPK FA/GSK-3α), up to -300% of the control level, in a time- and concentration-dependent manner. The maximal inductive effect on PDPK FA/GSK-3α also occurred within 40 min when cells were treated with only 100 mM ethanol. Similarly, exposure of NIH 3T3 cells to 100 μM cadmium for 2 h could induce a rapid increase in the protein level and cellular activity of PDPK FA/GSK-3α, up to -250% of the control level, in a time- and concentration-dependent manner. The maximal inductive effect on this kinase reached within 3 h when cells were treated with only 50 μM cadmium. The results demonstrate that PDPK FA/GSK-3α may not represent a constitutively active/mitogen-inactivated protein kinase as previously conceived. Taken together with the previous report that PDPK FA/GSK-3α is a heat-inducible protein kinase, the results further demonstrate that PDPK FA/GSK-3α may represent a typical cellular stresses-inducible protein kinase subject to early induction by heat, ethanol and cadmium. |
本系統中英文摘要資訊取自各篇刊載內容。