查詢結果分析
相關文獻
- Solid-Phase Extraction and Gas Chromatography-Mass Spectrometry Analysis of 11-Nor-9-carboxy-△抝-tetrahydrocannabinol in Urine for Monitoring Marijuana Abuse
- GAs Chromatography-Mass Spectrometry Analysis of 11-Nor-9-Carboxy-△勄-Tetrahydrocannabinol in Urine
- Gas Chromatography-Mass Spectrometry (GC-MS) Analysis of Amphetamine, Methamphetamine, 3,4-Methylenedioxy-amphetamine and 3,4-Methylenedioxymethamphetamine in Human Hair and Hair Sections
- 臺灣地區藥物濫用社會成本推估初報
- 國中導師成癮性藥物知識與藥物教育態度
- 中文版成癮嚴重度指標之修訂與信度評估
- 亞洲地區藥物濫用流行趨勢
- 安非他命罪犯人口資料暨犯罪行為分析
- 中學生藥物濫用認知、態度、行為及教育需求調查研究
- 藥物濫用個案家屬照顧需求及其相關因素之探討
頁籤選單縮合
題名 | Solid-Phase Extraction and Gas Chromatography-Mass Spectrometry Analysis of 11-Nor-9-carboxy-△抝-tetrahydrocannabinol in Urine for Monitoring Marijuana Abuse=以固相萃取法及氣相層析質譜儀分析尿中大麻代謝物監測大麻濫用者 |
---|---|
作者 | 蔡瑜瑩; 戴世傑; 黃明權; 張柏林; 廖俊亨; 劉瑞厚; | 書刊名 | 藥物食品分析 |
卷期 | 7:3 1999.09[民88.09] |
頁次 | 頁177-184 |
分類號 | 412.36 |
關鍵詞 | 氣相層析質譜分析; 氘內標準品; 尿中大麻代謝物; 藥物濫用; 11-nor-9-carboxy-△抝-tetrahydrocannabinol; GC-MS; Internal standard; Urine; Drug of abuse; |
語文 | 英文(English) |
中文摘要 | 本報告以固相萃取及甲基衍生化方法來分析尿中大麻代謝物11-nor-9-carboxy- △□-tetrahy-drocannabinol(9-THC-COOH),用以判定受檢者是否使用大麻。d□-9-THC-COOH 為內標準品,並以氣相層析質譜儀中之離子監測法(selected ion monitoring)做定性及定 量分析。監測9-THC-COOH離子為m/z 313,357,372;d□-9-THC-COOH離子為m/z 316,360,375。5mL空白尿液配製濃度15 ng/mL之9-THC-COOH時,其固相萃取之回收率大 於90%。以單點校正方式定量分析,最低可檢濃度為2.09 ng/mL;線性範圍位於4.18 ng/mL-376 ng/mL間;而線性範圍內之日間精密度試驗其變異係數(Coefficient of variation)為 1.49%-8.03%。 |
英文摘要 | A specimen pretreatment procedure, combining solid-phase extraction and methylation, was developed for the analysis of 11-nor-9-carboxy-△□- tetrahydrocannabinol (9-THC-COOH) in urine for monitoring marijuana exposure. d □-11-Nor-9-carboxy-△□-tetrahydrocannabinol (d□-9-THC-COOH) was used as an internal standard, while the now universal selected ion monitoring gas chromatography-mass spectrometry approach was used for detection (m/z 313, 357, 372 and 316, 360, 375 for 9-THC-COOH and d□-9-THC-COOH, respectively.) and quantitation (m/z 372 and 375 for 9-THC-COOH and d□-9-THC-COOH, respectively). The effectiveness of the overall procedure was evaluated. One of the extraction columns evaluated achieved > 90% recovery of the analyte in 5-mL drug-free urine fortified with 15 ng/mL 9-THC-COOH. Using the one-point calibration approach, the overall protocol achieved the following analytical parameters: detection limit: 2.09 ng/mL; limit of quantitation: 4.18 ng/mL; upper end of linear range: 376 ng/mL (or better); interday precision: 1.49-8.03% CV in th 4.18--376 ng/mL concentration range studied. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。