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題名 | 厚朴酚對腦缺血之治療評估 |
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作者 | 顏茂雄; | 書刊名 | 中醫藥年報 |
卷期 | 17:3 1999.05[民88.05] |
頁次 | 頁227-241 |
分類號 | 418.5 |
關鍵詞 | 氧游離基; 腦缺血; 再循環損傷; 厚朴酚; Cerebral ischemia; Magnolol; Reperfusion; Free radicals; |
語文 | 中文(Chinese) |
中文摘要 | 氧化謝物(Reactive Oxygen Metabolites;ROM),包括:過氧離 子、氫氧游離基以及過氧化氫,它是身體生理代謝反應及中樞神經 功能運作下之產物。ROM被認為和許多腦疾病之病變過程有關。關 於這方面已有許多研究報告間接證明:游離基氧化反應和腦外傷、 缺血、神經退化疾病如:巴金森氏症、老年癡呆症及多發性硬化等、 及神經中毒時引起組織損傷有關。基於上述有關游離基氧化物對於 神經病理角色之瞭解,目前正積極從基礎與臨床兩方面研究,以期 開發有效之抗氧化藥物,希望對因游離基引起之中樞病變有好的預 防與治療效果。在中醫方面,中藥厚朴(Magnolol officinalis)曾用於 多種處方,民間常用於治療發燒、頭痛、焦慮、腹瀉等。已知厚朴 酚magnolol為分離純化自厚朴之主要成分。根據最近文獻報導厚朴 中藥成份Magnolol具有強效之抗氧化作用,其抗氧化之強度約為 tocopherol之1000倍,為目前已知中藥成份與合成化合物中抗氧化 作用最強之藥物。因此本實驗以中樞腦缺血--再循環模式,探討厚朴 酚magnolol對缺血引起腦組織損傷之保護與治療效果。大白鼠經中 腦動脈結紮一小時後,給予再循環二十四小時。實驗結果顯示:厚 朴酚magnolol給藥組(15 & 60 ug/kg)可明顯改善腦缺血--再循環後之 腦組織壞死現象(控制組:150±21 mm��,magnolol 7.5:145±25 mm��, magnolol 15:75±22 mm��,magnolol 60:48±15 mm��),並且明顯降低腦 缺血--再循環後腦組織內之myeloperoxidase (MPO)含量(控制組: 60+10, magnolol 7.5:48±7, magnolol 15:25±5, magnolol 60:18±6 units/g wet weight)。由上結果顯示:厚朴酚 magnolol對腦缺血確實 具有良好的保護作用,且其所使用之劑量極低,可見其具有很強的 藥效,極具開發價值,期望未來可應用於臨床之疾病治療。 |
英文摘要 | Reactive oxygen metabolites (ROM), namely superoxide and hydroxyl free radicals and hydrogen peroxide, are produced as a consequence of the physiological metabolic reactions and functioning of the central nervous system. ROM have also been implicated in the processes of a number of pathological conditions of the brain. While primarily indirect, evidence for this view is accumulating, and credence for the participation of free radical oxidative interactions in promoting tissue injury in such conditions as brain trauma, ischaemia, and toxicity, and in neurodegenerative diseases such as Parkinson's disease, Alzheimer's dementia, multiple sclerosis, and lipofuscinosis, is growing. Concomitant with this new understanding of the injurious role free radical oxidants in neural pathology, is the increasing appreciation for the need for both fundamental and clinical research into the development of the potential preventative and therapeutic benefits that are now being foreseen for a variety of antioxidant nutritional and pharmacological interventions. In Chinese medicine, magnolol officinalis was included in many priscriptions. In traditional medicine, magnolol was used to treat fever, headache, anxiety, diarrhea etc. Magnolol, and active component, were extracted and purified from magnolol officinalis. Recently, it has been reported that magnolol is a potent antioxidant and free radicals scavenger. The antioxidant activity was 1000 fold of tocopherol. It is the most potent antioxidant of Chinese herbs, so far. Therefore, the aim of this project is to evaluate the effect of magnolol on the cerebral ischemia-reperfusion injury model in rats. Results demonstrated that treatment of magnolol (15 & 60 ug/kg) could significantly reduce the infarct volume induced by 1 hr middle cerebral artery ligation followed by 24 hr reperfusion (control: 150±21 mm��, magnolol 7.5:145±25mm�纂Amagnolol 15:75±22 mm��, magnolol 60:48±15mm��). Similarly, magnolol treatment (15 & 60 ug/kg) groups, a significant reduction of the activity of myeloperoxidase in ischemic region was observed (control: 60±10, magnolol 7.5: 48±7, magnolol 15: 25±5, magnolol 60: 18±6 units/g wet weight).In conclusion, magnolol possesses a pronounced cerebroprotective effect in rats. This effect may be achieved by its antioxidant action and suppressing neutrophils migration. Magnolol is a potential drug to be applied clinically in future. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。