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題 名 | 進行性肌肉萎縮症中藥療效之評估--肌胚細胞培養及動物實驗之研究(第一年)=Therapeutic Method for Progressive Muscular Dystrophy with Herbal Extract Compound: Study on Myoblast Culture and Animal Model |
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作 者 | 陳順勝; | 書刊名 | 中醫藥年報 |
卷 期 | 17:3 1999.05[民88.05] |
頁 次 | 頁197-226 |
分類號 | 413.3 |
關鍵詞 | 進行性肌肉萎縮症; 肌胚細胞培養; 活動量記錄; Muscular dystrophy; Myoblast transplantation; Locomotor activity; |
語 文 | 中文(Chinese) |
中文摘要 | 本研究計畫重點在於嘗試以中藥來治療杜顯型及貝克型肌肉萎 縮症(Duchenne and Becker type muscular dysrophy,以下簡稱DMD 及BMD)。DMD及BMD由於基因缺陷導致肌肉內dystrophin缺乏,因 此矯正基困缺陷和補充缺陷蛋質成為本病的治療方針。由於基因 療法的技術困難,需進一步研究。而細胞療法,即將肌胚細胞 (myoblast)移植入病肌內,並使正常肌細胞與疾病肌細胞融合,恢復 產生dystrophin能力成為探索本病治療的權宜新技術。肌胚細胞療法 仍有許多待解決之困難處,如細胞培養技術的建立、移植後的組織 排斥現象等等,針對這些目前尚待改進及在基礎醫學或臨床上有爭 論之處。目前的問題在於如何改善肌胚細胞培養之量產及如何在移 植後增加肌胚細胞之存活率。本研究以先天dystro-phin蛋白缺損小 鼠(MDX)做為研究材料,探討中藥複方對肌胚細胞生長以及MDX 小鼠活動量之影響。在為期3個月的中藥複方投與後,發現左歸丸和 六味地黃丸可改善MDX小鼠垂直活動的表現,並且亦具有增進肌胚 細胞生長的能力。其餘7種小藥複方均無法在兩項實驗項目中獲得改 善的目的。 |
英文摘要 | Duchenne and Becker type muscular dystrophy (DMD/BMD) is a hereditary muscular dystrophy caused by genetic abnormality. The shortage of dystrophin, the protein product of this gene, is the main reason of this disease. Study of therapeutic methods toward DMD/BMD is based on the correction of genetic deficiency and the supplement of deficient dystrophin. While gene terapy still remains many problems to be resolved, the myoblast transplantation has become an efficient method toward DMD/BMD therapy. The prospect of myoblast transplantation is to introduce normal myoblasts into DMD/BMD dystrophic muscle, and then the effected muscle will produce dystrophin. The recent problem of myoblast transplantation is how to establish a good method for mass produce of myoblasts and to raise the survival rate of transplanted myoblasts. In this study, nine types of herbal extract compound were used in this study to access whether these traditional medicines could provide some useful treatments for DMD/BMD therapy. We use myoblast culture treated with herbal extract compounds to access the effect of these compounds on myoblast proliferation, another experiment using locomotor activity to access the effect on muscle strength. The results show that within nine types of herbal extract compound, two of them reveal facilitation of vertical activity and cell growth, while other compounds have no effect on both tasks. |
本系統中英文摘要資訊取自各篇刊載內容。