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題名 | 癲癇的中西醫學整合研究中藥方柴胡加龍骨牡蠣湯的實驗抗癲癇作用基礎研究(5-1)=The Integration of Chinese and Western Medicine in Epilepsy Research the Experimental Study of Antiepileptic Effect of the Chinese Herbal Mixture"Chai-Hu-Long-Ku-Mu-Li-Tan"(5-1) |
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作者 | 蔡景仁; 吳鴻明; 許桂森; 簡伯武; 劉青山; | 書刊名 | 中醫藥年報 |
卷期 | 17:3 1999.05[民88.05] |
頁次 | 頁1-19 |
分類號 | 414.5 |
關鍵詞 | 柴胡加龍骨牡蠣湯; 癲癇; 抽搐藥品; Chinese mechicine; Chai-hu-long-ku-mu-li-tan; Epilepsy; |
語文 | 中文(Chinese) |
中文摘要 | 本研究宗旨在探討柴胡加龍骨牡蠣湯加減方(TW-001)對於癲癇發作動物Sprague-Dawley鼠(大鼠)模式的抗癲癇效果及作用機制。癲癇發作之誘發採用皮下注射Pentylenetetrazol(PTZ)及Picrotoxin(PX)兩種致抽搐劑。利用Loscher及Honack氏及Akarsu氏量表同時分析大鼠癲癇發作時行為變化,並作為痲癇發作之量化標準。大鼠分組餵食安慰劑每天2克/公斤,TW-001每天1克/公斤、每天2克/公斤或每天4克/公斤。大鼠餵食TW-001一小時後即施予PTZ及PX測試為急性試驗,餵食2週後測試為慢性試驗。在急性試驗,TW-001每天2克/公斤及4克/公斤組可明顯降低PTZ誘發大鼠痲癇發作的發生率(安慰劑組89%,TW-001每天2克/公斤組60%,TW-001每天4克/公斤組50%,P < 0.05)及嚴重度,並且其有劑量正相關性傾向。TW-001每天1公克/公斤及2克/公斤組對PX誘發大鼠癲癇發作則無明顯效用。在慢性試驗,餵食TW-001每天2克/公斤及4克/公斤組明顯降低PTZ誘發大鼠抽搐的發生率(安忍劑組80%,TW-001每天2/公斤組58%,TW-001每天4克/公斤組67%,P < 0.05),對PX,TW-001每天2克/公斤組可明顯降低發生率(安忍劑組70%,TW-001每天2克/公斤組55%,P < 0.05)。鑑別分析抽搐閾值耐受量研究之急性試驗時,一次服用TW-0014克/公斤組可明顯增加對PTZ的耐受量,而對PX則無明顯增加;在慢性試驗時,慢性餵食TW-001每天4克/公斤組對PTZ亦顯著地增加耐受量,而對PX的耐受量則無明顯增加。本實驗包括急性、慢性灌食安忍劑與不同劑量之TW-001對於PTZ及PX之誘發大鼠癲癇發作之發性率及對PTZ及PX誘發大鼠癲癇發作之耐受量之結果一致,顯示TW-001在癲癇動物鑑定實驗確實具有抗癲癇的作用。另外,本實驗的新發現為TW-001對PTZ所誘發之抽搐有效,但對PX所誘發之抽搐則效果不佳,其可能原因為TW-001的作用位置並不在GABA�楊�體上的PX作用部位,而是在TBPT(t-butyl-bicyclophospho rothionate)作用部位,此仍有待進一步証實。 |
英文摘要 | This study was undertaken to evaluate the antiepileptic prtentiality of the Chinese herbal mixture "Chai-Hu-Long-Ku-Mu-Li-Tan"(tw-001) during pentylenetetrazol (PTZ) and picrotoxin induced seizures in Sprague-Dawley rats. The behavioral responses displayed by the animal to PTZ and picrotoxin injection were measured by scores designed by Loscher and Honack, and by Akarsu et al. In identification studies, the incidence and the intensity of generalized tonic clonic convulsions were significantly decreased when PTZ was injected subcutaneously at dose of 65 mg/kg to rats one hour after being fed with TW-001 2gm/kg (60%), TW-001 4gm/kg (50%)in comparison with placebo group (89%) and 2 weeks after being fed with TW-001 2gm/kg/day (58%), TW-001 4gm/kg/day(67%)in comparison with placebo group (80%), TW-001 DID not inhibit the incidence and the intensity of seizure in rats one hour after beig fed with TW-001 2 gm/kg, but the incidence of generalized tonicclonic convulsions were significantly decreased in rats fed with TW-001 2 gm/kg for 2 weeks when picrotoxin was injected subcutaneously at 3.5gm/kg. In differentiation studies, it was found that TW-001 significantly increased the tolerant amount of PTZ which was intravenously infused to induce experimental convulsion to rats one hour after being fed with TW-001 4gm/kg and 2 weeks after being fed with TW-001 4 gm/kg/day, respectively. However, TW-001 did not significantly increase the total dosage of picrotoxin for the induction of seizures in rats one hour after being fed with 4gm/kg and 2 weeks after being fed with 4gm/kg/day. The results show that TW-001 has antiepileptic activity based on both acute and chronic experimental designs for the incidence of generalized cconvulsion as well as the seizure threshold in response to PTZ and picrotoxin. Furthermore, TW-001 is more effective in the prevention of PTZ induced seizure. The discrepancy of the effect of TW-001 in response to PTZ and PX is probabley due to the action site of TW-001 on TBPT rather than on PX over the GABA�斟eceptors. This hypothesis needs to be confirmed. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。