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題名 | 針灸抑制癲癇發作機轉之研究=A Study on the Mechanism of Acupuncture in Suppressing Epileptic Seizure |
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作者 | 沈淵瑤; 賴宇俊; | 書刊名 | 中醫藥年報 |
卷期 | 17:3 1999.05[民88.05] |
頁次 | 頁121-148 |
分類號 | 413.34、413.34 |
關鍵詞 | 癲癇; 針灸; 麩胺酸; 微量透析技術; 腦電波; Epilepsy; Acupuncture; Glutamate; Microdialysis; EEG; |
語文 | 中文(Chinese) |
中文摘要 | 在臺灣依然有大約十萬人為癲癇所苦。其中大部份病人幾乎終其一生都必須服用抗癲癇藥物,才可避免受痲癇發作的痛苦。然而這些藥物常有抑制神經正常生理的作用,因而有些病人不願完成規則性的治療,所以找尋另一種治療痲癇方式是必需的。 針灸在中國盛行已超過二千餘年,它是項古老且有別於現今醫學的治療方式,此項技術雖然古老但也受目前醫學的重視。一般而言針灸所能治療的疾病大部份與神經系統有關。許多文獻指出,針灸且有減少癲癇發作的治療效果、而且就我們所知,針灸是經由人體自身的調節方式補虛瀉實,所以較少有嚴重副作用。由於針灸有上述這些觀點,所以本研究室便非常有興趣來了解針灸是如何的作用機轉來抑制癲癇的發作。 在本研究中,成熟雄性大白鼠以氨基鉀酸酯(1.7g/kg,i.p.)麻醉,盤林西林(1336U)注入海馬迴使動物產生連續性的抽搐。我們利用腦電波儀及微量透析等方式來監測動物腦中海馬迴之腦電波及特定胺基酸濃度變化,以藥物盤林西林直接微量注射入腦中海馬迴的部位,便可引發動物產生類似癲癇之連續性的抽搐。針灸則施以治療,我們則觀察針灸對於基礎狀況及癲癇狀況動物腦部腦電波的變化及特定胺基酸濃度變化有何影響。 在本研究中的結困發現無論手針或電針的施予,都未發現對於基礎狀況的大白鼠腦電波及特定胺基酸濃度有任何改變。手針及電針皆未發現可以抑制大白鼠癲癇腦電波現象。我們發現電針(15mA, 6Hz)長強Gv1)及合鈶(Li4)二個穴位皆可發現大白鼠腦中海馬迴位置中對於藥物所引發癲癇,致使興奮性麩胺酸腦中濃度上升有明顯被抑制下來。就我們所得成果資料解釋,針灸可能無足夠的治療強度能單獨使用治療癲癇所引起的抽搐,但是應可以輔助他種治療的醫療方法。本研究成果建議針灸抑制癲癇發作作用可能是經由抑制腦中麩胺酸濃度上升而成。 |
英文摘要 | There are about one hundred thousand persons still suffer from epilepsy in Taiwan. Most of the patients have to take anti-epileptic drugs all their life. The drug commonly have serious neurologic side-effect. According some patients are reluctant to regular anticonvulsant therapy. Acupuncture has been used in China for over two millennia. It is an old and special therapeutic technique, as well as a young and developing medical in the world. Acupuncture is used to treat many diseases which are related to the nervous ststem. In many reports point out acupuncture can supress epilepstic seizure. To our knowledge, acupuncture in seldom appear serious side-effects in treatment procedures because its curative effects are via own body regulation. We are very interesting to wonder about the suppressing mechanism of acupuncture to epilepsy. In our study, we tried to study electroencephalogrophy (EEG) and amino acids (AAs)levels change in animal's hippocampus in basic condition and epleptic seizure condition after acupcncture was used. Adult, male Sprague-Dawley rats anesthetiaed with urethane(1.7g/kg, i.p.) were used in this experiment. Penicillin (1336U)injected into hippocampus that used to induce seizure in animal. We sued electroencephalogramer to moniter EEG of animal's brain and microdialysis technique to monitor AAs levels in hippocampus. There is no change of EEG and AAs levels at basic condition no matter acupuncture with or without electric stimulation (15mA, 6Hz). Acupuncture and electroacupuncture (E-acup.) did not reduce the epileptic seizure wave number and amplitude in EEG induced by penicillin. We found the increased of glutamate levels in the hippocampus which induced by penicillin, would be significantly suppressed by E-acup. at Changchiang (TM1)and Hoku(IC4). Base on our data, acupuncture might be not strong enough to trea epileptic seizure by it alone, but it might be an auxiliary treatment in epileptic seizure. However, acupuncture suppressing epileptic seizure might be via supressed the increasing level o f glutamate at the brain. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。