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頁籤選單縮合
題名 | Paget's Disease of the Tibia=脛骨的Paget氏病一病例報告 |
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作者 | 王崇禮; 吳振都; 簡君儒; 韓毅雄; | 書刊名 | 臺灣醫學會雜誌 |
卷期 | 98:6 1999.06[民88.06] |
頁次 | 頁444-447 |
分類號 | 416.261 |
關鍵詞 | 脛骨; Paget氏病; Paget's disease; Bone; Calcium; Alkaline phosphatase; Epidemiology; |
語文 | 英文(English) |
英文摘要 | Paget's disease of the bone is perceived to be rare in Asia. We report the first documented case of Paget's disease of the bones in Taiwan. A 66-year-old native Taiwanese woman was admitted to hospital with a 10-vear history of pain and a bowing deformity of her left leg. Laboratory data disclosed elevated serum calcium and alkaline phosphatase levels, but no leukocytosis. A plain X-ray film of the left leg showed a curved tibia with thickening of the tibial cortex, while a technetium 99m bone scan revealed abnormal uptake in the left tibia. Elevated serum levels of bone-specific alkaline phosphatase and urinary collagen N-telopeptide were also noted. Histologic examination of a biopsy specimen of the left tibia lesion confirmed the diagnosis of Paget's disease in the bone. The patient received treatment with sodium chlodronate, and the symptoms improved rapidly. Laboratory data then revealed decreased levels of serum calcium, bone-specific alkaline phosphatase, and urinary collagen N-telopeptide after treatment. |
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