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題名 | Plasma Concentrations of Interferon-α in Patients with Liver Cirrhosis: Relationship to Systemic and Portal Hemodynamics=肝硬化病人血漿α-干擾素之濃度:系統及門脈血流動力學之關係 |
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作者 | 王雅瑜; 朱啟仁; 李發耀; 張扶陽; 林漢傑; 盧瑞華; 詹哲彰; 王德芳; 王聖賢; 李壽東; | 書刊名 | 中華醫學雜誌 |
卷期 | 62:4 1999.04[民88.04] |
頁次 | 頁195-202 |
分類號 | 415.534 |
關鍵詞 | 肝硬化; 血流動力學; α-干擾素; Cirrhosis; Hemodynamics; Interferon-α; |
語文 | 英文(English) |
中文摘要 | 背景一氧化氮在門脈高壓之高血流動力循環之病理機轉上扮演著重要的角色。α -干擾素( IFN- α)可直接或間接透過細胞素而刺激一氧化氮之形成。然而,過去的研究 顯示肝硬化病人血漿 INF- α之濃度可以增加或減少。本研究探討肝硬化病人血漿 IFN- α 濃度及其與系統及門脈血流動力學之關係。 方法以�t聯免疫吸附分析法( ELISA )測定 36 位肝硬化病人及 47 位健康對照者之血漿 IFN- α濃度。另外,以 Swan-Ganz 導管插入及熱稀釋法測定肝硬化病人之系統及門脈血流 動力學參數。 結果肝硬化病人比健康人有較高之 IFN- α可測得率( >3pg/ml,36.1% 對 14.9%,P<0.05 )。在肝硬化病人中,不論有無肝功能代償失調,肝靜脈壓差大於 12mmHg 或是出現大食道 靜脈曲張,IFN- α的可測得率都相似( p>0.05 )。而肝硬化病人不論可否測得血漿 IFN- α,其系統性血管阻力及肝靜脈壓差均無顯著差異。 結論肝硬化病人血漿 IFN- α的濃度有增加的現象,然而 IFN- α在肝硬化病人之高血流動 力循環中並不扮演重要的角色。 |
英文摘要 | BACKGROUND: Nitric oxide (NO) plays an important role in the pathogenesis of the hyperdynamic circulation observed in portal hypertensive states. Interferon (IFN)-alpha can stimulate NO formation directly or indirectly via cytokines. However, IFN-alpha concentrations seem to increase or decrease in cirrhotic patients. This study investigated the plasma concentration of IFN-alpha in patients with cirrhosis and its relationship to systemic and portal hemodynamics. METHODS: Thirty-six patients with cirrhosis and 47 healthy controls had blood samples taken for the determination of plasma concentrations of IFN-alpha by enzyme-linked immunosorbent assay. Systemic and portal hemodynamics were measured in patients with cirrhosis on the same day of blood sampling using Swan- Ganz catheterization and the thermodilution technique. RESULTS: As compared with healthy subjects, patients with cirrhosis demonstrated a significantly higher IFN-alpha detectable rate (> 3 pg/ml, 14.9% vs 36.1%, p < 0.05). In cirrhotic patients, the IFN-alpha detectable rates were similar between those with and without decompensation, a hepatic venous pressure gradient greater than 12 mmHg, or the presence of large esophageal varices (p > 0.05). There was no significant difference in the systemic vascular resistance or hepatic venous pressure gradient between cirrhotic patients with and without a detectable plasma IFN-alpha concentration. CONCLUSIONS: Plasma IFN-alpha concentrations tended to increase in patients with cirrhosis. However, IFN-alpha concentrations do not play a role in the hyperdynamic circulation observed in patients with cirrhosis. |
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