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題 名 | Attenuation of Basilar Artery Spasm after Experimental Subarachnoid Hemorrhage in Rabbit by Potassium Channel Activator Cromakalim-A Preliminary Result=鉀離子通道活化劑cromakalim在動物實驗蜘蛛膜下腔出血引發腦血管痙攣的效果 |
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作 者 | 關皚麗; 林志隆; 洪純隆; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 15:5 1999.05[民88.05] |
頁 次 | 頁268-273 |
分類號 | 418.22 |
關鍵詞 | 鉀離子通道活化劑; 蜘蛛膜下腔出血; 腦血管痙攣; K+ channel; Cromakalim; Vasospasm; |
語 文 | 英文(English) |
中文摘要 | 由動脈瘤引起的蜘蛛膜下腔出血併發的腦血管痙孿依然是無法預測與適當治療的。而經由活化或抑制鉀離子通道來調節血管平滑肌,提供了一個重要的機轉來舒張或收縮血管。鉀離子通道活化劑cromakalim在活體或體外實驗選擇性地舒張由蜘蛛膜下腔出血引發的腦血管痙孿,因此可以應用在治療腦血管痙孿。為了評估其效應,我們研究在蜘蛛膜下腔出血的兔子實驗模式上使用cromakalim的效果。實驗是在誘發蜘蛛膜下腔出血後,利用局部和動脈注射的方法,檢查cromakalim在免子基底動脈的效果。而基底動脈在蝶骨後斜坡上被顯見出來後立即用顯微攝影測量基底動脈的變化。實驗得知蜘蛛膜下腔出血併發的腦血管痙攣,可以經由局部和動脈注射cromakalim得到舒解。而此效果是與劑量有相關的。在經由局部和動脈注射的效果並無顯著差異。這些結果說明了鉀離子通道活化劑cromakalim在改善腦血管痙攣上扮演一個重要的角色,也提供在做血管攝影時注射cromakalim來治療腦血管痙攣的可能性。 |
英文摘要 | Cerebral vasospasm associated with aneurysmal subarachnoid hemorrhage (SAH) remains a major complcation in patients suffering from SAH. Regulation of membrane potential of arterial smooth muscle through activation or inhibition of potassium (K+) channel activity provides an important mechanism to dilate or constrict arteries. The present study examined the effect of a K+ channel activator, cromakalim, on cerebral vasospasm following experimental SAH. By the route of topical application and intra-arterial injection, basilar arteries were exposed transclivally and measured on-line using videomicroscopic camera. Continuous microinjection from right vertebral artery was given after the result of application was observed. Basilar artery spasm induced by SAH was released by topical or intraarterial administration of cromakalim, and this beneficial effect against cerebral vasospasm was dose-dependent. There was no significant difference between topical and intra-arterial administration of cromakalim. These results indicate that K+ channel activator may play an important role for ameliorating cerebral vasospasm. An important goal of future studies will be to carefully evaluate the possibility and effect of intra-arterial administration of cromakalim to treat angiographic vasospasm. |
本系統中英文摘要資訊取自各篇刊載內容。