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頁籤選單縮合
題 名 | Intraocular Use of Fluconazole in the Management of Ocular Fungal Infection=眼球內注射Fluconazole用於治療眼球內黴菌感染 |
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作 者 | 蘇娟儀; 林昌平; 王惠珠; 蘇明揚; 蔡榮坤; 吳國揚; 許明木; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 15:4 1999.04[民88.04] |
頁 次 | 頁218-225 |
分類號 | 418.284 |
關鍵詞 | 眼球; 黴菌感染; Fungal endophthalmitis; Keratomycosis; Fluconazole; |
語 文 | 英文(English) |
中文摘要 | 為探討眼球內注射fluconazole用於治療眼球內黴菌感染之效果以及安全性;我們搜集十位眼球內黴菌感染、兩位為黴菌性眼內炎,這些病人在傳統治療無法有效控制感染後,都曾接受眼球內注射fluconazole的治療,包括前房灌洗、前房內注射或玻璃體內注射,使用濃度為5-10μg/ml。其中九位經治療後黴菌感染獲得有效控制、停藥後未再復發,一位則無法控制、最後眼球摘除。我們的結果顯示以眼球內注射fluconazole來治療嚴重眼球黴菌感染安全而有效。我們建議這樣的治療方法可以做為另一種選擇;不但可以避免全身的副作用,也可以節省治療時間。適當的使用濃度則需要更多的研究。 |
英文摘要 | In this study, we investigate the efficacy and safety of intraocular use of fluconazole in the treatment of ocular fungal infection. Ten patients with intraocular fungal infections were examined. Among these patients, eight were infected with keratomycosis with intraocular spreading, one had postoperative fungal endophthalmitis after cataract operation with an intraocular lens implant, and another suffered from endogenous fungal endophthalmitis. In addition to the conventional local application with or without systemic administration of antifungal drugs, all ten patients were treated with intraocular administration of 5-10 μg/ml of fluconazole. The ocular fungal infections resolved in nine patients without obvious side effect. One failed in the antifungal treatment with loss of vision. In our experience, the results revealed that fluconazole is a safe and effective antifungal agent that can be administered intraocularly. We suggest that intraocular administration of this drug could be considered as an alternative or additional choice for the treatment of severe ocular fungal infections. |
本系統中英文摘要資訊取自各篇刊載內容。