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題 名 | Evaluation of the Protection Efficacy of Newcastle Disease Vaccination Programs=新城雞病免疫計畫保護效力之評估 |
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作 者 | 蔡向榮; 林地發; | 書刊名 | 中華民國獸醫學會雜誌 |
卷 期 | 25:1 1999.03[民88.03] |
頁 次 | 頁1-7 |
分類號 | 437.717 |
關鍵詞 | 新城雞病; 免疫計劃; 保護效力; Newcastle disease; ND; Vaccination programs; Protection efficacy; |
語 文 | 英文(English) |
中文摘要 | 在本研究中對數種新城雞病(Newcastle disease)之免疫計畫以強毒株攻毒的方式 評估其保護效力。在試驗1中,12組SPF雞隻在4日齡時以ND活毒(L)或不活化疫苗(K)免疫 後,在7日齡或14日齡再以活毒(L)或不活化疫苗(K)補強一次,各組在5週齡時以103LD50佐 藤株ND病毒株攻毒時都有良好的保護力(80-100%)。在試驗2及3中,具有高移行抗體之肉雛 雞(在4日齡時之幾何平均ND血球凝集抑制抗體力價為1:84.5-1:135),部份組別在4日齡同 時以活毒及不活化疫苗(L+K)接種,然後在17日齡時接種活毒疫苗(L),其他組別則是在4日 齡以活毒疫苗(L)接種後,再在14日齡以不活化疫苗(K)接種,在17日齡時再以活毒疫苗(L) 接種一次。活毒疫苗皆以點眼的方式接種,不活化疫苗皆以皮下的方式接種。二種疫苗接種計 畫在5週齡攻毒時都有很好的保護效果(80-100%),但如果在3週齡或4週齡攻毒時,後者 [4(L),14(K),17(L)]之保護率(100%)顯著較前者[4(L+K),17(L)]之保護率為高 (50-80%)(p<0.05)。 |
英文摘要 | Various Newcastle disease (ND) vaccination programs were tested for their protection efficacy. In trial 1, SPF chicks were vaccinated with an attenuated or inactivated ND vaccine at 4-day-old, then boosted again with an attenuated or inactivated ND vaccine at 7 days of age or 14 days of age. All vaccinated groups showed a good protection rate (80-100%) when they were challenged with a virulent ND virus at 5-week-old. In trials 2 and 3, several groups of broilers with high maternal antibodies (geometric mean hemagglutination-inhibition antibody titer was 1:84.5-1:135 at 4-day-old) were simultaneously immunized with an attenuated and an inactivated ND vaccine at 4 days of age, and then revaccinated with an attenuated ND vaccine at 17-day-old. Other groups of broilers were first vaccinated with a live vaccine at 4-day-old, revaccinated with an inactivated vaccine at 14-day-old, and then boosted again with a live vaccine at 17-day-old. Good protection rate (80-100%) was achieved in both groups when they were challenged at 5-week-old. When they were challenged at 3-week-old and 4-week-old, the latter broiler groups had a significantly higher protection rate (100%) than the formal broiler groups (50-80%)(p<0.05). |
本系統中英文摘要資訊取自各篇刊載內容。