查詢結果分析
來源資料
相關文獻
- T Lymphocytes and Cytokine Production in Ascitic Fluid of Ovarian Malignancies
- Serum Endothelin and Atrial Natriuretic Peptide in Cirrhotic Patients with Ascites and Hepatorenal Syndrome
- A Huge Ovarian Solid Tumor with Massive Ascites: A Case Report
- 肝性腹水病患對低鹽飲食的認知、態度與遵從行為之探討
- 中藥對過敏性鼻炎治療之免疫機轉研究
- 腎氣丸對塵蟍激發喘天竺鼠呼吸道發炎與免疫之影響
- 急性躁期患者細胞免疫功能之活化
- 氣功外氣對人類早期單核細胞株和流行性感冒病毒的效應
- 等速肌力訓練對細胞激素IL-6和IFN-γ的影響
- 細胞激素在急性胰臟炎的病因學上扮演的角色
頁籤選單縮合
題名 | T Lymphocytes and Cytokine Production in Ascitic Fluid of Ovarian Malignancies=惡性卵巢腫瘤的腹水中之T淋巴球及細胞激素表現 |
---|---|
作者 | 陳俊凱; 吳明義; 趙光漢; 何弘能; 許博欽; 黃思誠; | 書刊名 | 臺灣醫學會雜誌 |
卷期 | 98:1 1999.01[民88.01] |
頁次 | 頁24-30 |
分類號 | 417.25 |
關鍵詞 | 惡性卵巢腫瘤; 腹水; T淋巴球; 細胞激素; Ovarian malignancy; Ascitic fluid T lymphocyte; Activation marker; Cytokines; Soluble interleukin-2 receptor; |
語文 | 英文(English) |
英文摘要 | The activation status of T lymphocytes and the presence of various cytokines in ascitic fluid were examined to test peritoneal immunity in women with ovarian malignancies. Peripheral blood and peritoneal fluid were collected from 12 patients with primary ovarian cancer with ascites and 27 normal control subjects during laparoscopic examination. Lymphocyte subpopulations and the expression of activation markers on T lymphocytes were analyzed by dual-color flow cytometry. The concentrations of various cytokines and soluble interleukin (IL)-2 receptor-α were measured. CD8 T lymphocytes were the main component of peritoneal lymphocytes. CD69 and HLA-DR, but not CD25, were highly expressed on peritoneal T lymphocytes compared to those in peripheral blood. In ascitic fluid of ovarian malignancies, CD4 T lymphocyte concentrations were further decreased, resulting in a decreased CD4/ CD8 ratio. Decreased expression of CD69 and CD25 was also noted on T lymphocytes from ascites compared with T lymphocytes in normal peritoneal fluid. IL-1b. tumor necrosis factor-α, IL-6, and soluble IL-2 receptor-α concentrations were increased significantly in the ascitic fluid of women with ovarian cancer. The decrease in activation markers on T lymphocytes is suggestive of an immunosuppressive state, despite the presence of abundant stimulatory cytokines. The immunosuppression may be multifactorial, attributed, in part. to the increased concentrations of soluble IL-2 receptor-a and other inhibitors. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。