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題 名 | 運動對SD大鼠內皮細胞內分泌功能的影響=The Effects of Exercise on the Endocrine Function of Endocrine in SD Rats |
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作 者 | 姚東生; | 書刊名 | 華夏學報 |
卷 期 | 33 1998.12[民87.12] |
頁 次 | 頁14221-14257 |
分類號 | 528.9012 |
關鍵詞 | 運動; 內皮細胞內分泌; 內皮素; |
語 文 | 中文(Chinese) |
中文摘要 | 為了探討機體在不同運動量的急性運動或運動訓練中,機體內皮細胞內分泌功能 的變化,及與機體氧自由基代謝之間的關係,經由對 SD 大鼠進行不同運動量的急性游泳運 動和為期八週的游泳訓練,測定血漿內皮素(ET)含量和血清一氧化氮(NO)含量,並測定 血清超氧化物歧化(SOD) 活力和丙二醛(MDA)含量。結果:1.急性運動中,血漿 ET 含量隨著運動量的漸增而逐漸增加。實驗得知大運動量的急性運動可促進機體 ET 的分泌 ,並與運動強度和運動時間有關。同時,隨著運動量的漸增,血清 NO 含量先逐漸增加,但 運動量增加到一定程度時,血清 NO 含量開始下降。證明適量的急性運動可促進內皮細胞 NO 的分泌,但過大量的力竭性運動可抑制 NO 的分泌。2. 在適量的急性運動中,SD 大 鼠血 ET/NO 值下降,進而導致機體組織中,特別是骨骼肌,血管阻力下降,血流量增 加,有利於營養物質、氧氣的供應和代謝產物的清除;而過大運動量的力竭性運動後,SD 大鼠血 ET/NO 值下降,進而使血管收縮,外周阻力增加,機體組織特別是骨骼肌和心肌 ,缺氧、缺血,導致運動能力下降和運動疲勞產生。3.適量的運動訓練可使大鼠血漿 ET 含量下降,使用血清 NO 含量升高,且 ET/NO 值下降。證明中、小強度的運動訓練可 增加內皮細胞 NO 的分泌,而抑制 ET 的分泌。因此,適量的運動訓練對降低一般人或輕 度高血壓患者的血壓有正面的影響。4.適量的急性運動可使機體抗氧化能力提高,或使機 體氧自由基的生成與清除處於良好狀態;而長時間大強度的力竭性運動可降低機體清除氧自 由基的能力。同時,適量的運動訓練也可增強機體清除氧自由基的能力,而長期大強度的運 動訓練可使機體清除氧自由基的能力下降。5.研究得知,機體內血漿 ET 含量與血清 SOD/MDA 值呈弱負相關,血清 NO 含量與 SOD/MDA 值呈顯著正相關,且 ET/NO 與血清 SOD/MDA 值呈顯著負相關。說明機體抗氧化能力增強時,可抑制 ET 的分泌和促進 NO 的分 泌。因此,長時間的力竭性運動或長期大強度的運動訓練,機體 SOD 活力下降,MDA 含 量升高,可能是導致機體 ET 分泌增多, NO 分泌減少的生理機制。 |
英文摘要 | The purpose of this study was to discuss and inquire into the changes of endocrine function of endothelium and the relationship between oxygen free radicals metabolism and it in physical training or acute exercise of different load. The contents of plasma endothelin(ET), serum nitric oxide (NO), and MDA, and the activity of serun SOD in SD rats were tested and determined during acute exercise or after 8 weeks swimming training of different load. Results showed that: 1.The plasma ET content increased with the increas of exercise load in acute exercise, it indicated that exercise of heavy load could promote the Etsecretion, which had something to do with the intesity and time of exercising. t the same time, the serum NO content increased with increase of exercise load either, but, to some extent, it decreased. This indicated further that properload of exercise could promote the NO secretion of endothelium and overloaded exhaustive exercising could restrain the secretion of it. 2. The decrease of the rato of ET and NO(ET/NO) in blood of rats in proper load exercising. Resulted in a decrease of vascular resistance and a increase of blood flow in organism, especially in skeletal muscle and myocardium, which was good for the supply of nutrition and oxygen and the elimination of metabolic waste; The decrease of ET/NO after exhaustive exercising brought about vasocontraction and a increase of peripheral resistance, the ischemia and hypoxia in skeletal muscle and myocardium. Therefore it led to a decline in exercising ability and fatigue. 3.The plasma ET content decreased and serum NO content increased through proper exercise training, which made the ratio ET and NO decreased. This indicated that light or moderate exercise training could enhance the NO secretion of endothelium and restrain the ET secretion. Therefore proper exercise training had good influence on the drop of blood pressure in normotensive or mildly hypertensive humans. 4.Proper exercising could raise orgganism's ability of oxidation-resistance, or make the production and elimination of oxygen free radicals in high state. On the contrary, the organism's ability of elimination of oxygen free radicals was weakened by long time exhaustive exercising or by long period of overload training. 5. The study showed further that the interrelationship of plasma ET content and serum SOD/MDA was inferior negative; the interrelation of serum NO concent and SOD/MAD was postive signigicantly, ET/NO and SOD/MDA NEGATIVE SIGNIFICANTLY. This proved that the secretion of ET could be restrained and that of NO could be promoted when organism's ability of oxidation-resistance was rased, it was conclueded that the decrease of SOD activity and the increase of MDA production after long-time exhaustive exercise or long period of overload training might be the physiological mechanism of the increase of ER production and decrease of NO production resulting from the chandes in the investigation. |
本系統中英文摘要資訊取自各篇刊載內容。