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頁籤選單縮合
題 名 | 敗血性巴氏桿菌類毒素疫苗之研製=Dermonecrotic Toxoid Vaccine of Pasteurella Multocida Type D |
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作 者 | 吳義興; 陳素貞; 張惟茗; 蕭終融; | 書刊名 | 臺灣省家畜衛生試驗所研究報告 |
卷 期 | 34 1998.12[民87.12] |
頁 次 | 頁61-67 |
分類號 | 437.245 |
關鍵詞 | 敗血巴氏桿菌; 類毒素; 疫苗; Pasteurella multocida; Toxoid; Vaccine; |
語 文 | 中文(Chinese) |
中文摘要 | 由14株敗血性巴氏桿菌D群分離株,選出2株可產生天竺鼠皮膚壞死性毒素者, 經培養於含 5% 代血清之腦心浸液培養基 20 小時,經離心所收集之菌體以超音波打擊抽取 其毒素而製成粗製毒素,經測定其蛋白質含量後, 調整其濃度為每 ml 含 1mg 之蛋白質液 ,其對天竺鼠皮膚壞死反應力價為 32 倍,即約 3ug 即可引起反應。 粗製毒素經管柱分離 後產生之純化毒素,約 6ng 即可引起天竺鼠皮膚壞死反應。 粗製毒素以甲醛不活化後,加 入不活化巴氏桿菌及鋁膠佐劑製成類毒素疫苗,試製成之類毒素疫苗免疫小白鼠後,再以活 菌攻擊, 結果其防禦指數依不添加或添加不活化菌体菌苗,分別為對數指數 1.75 與 1.93 。天竺鼠免疫 2 次後,以 10 LD �t攻擊之結果防禦力各為 75% 及 100%,懷孕母豬分娩前 5 及 3 週各免疫 1 次及小豬 1 週齡及 3 週齡各免疫 1 次,其安全性百分之百, 無任何 不良反應,免疫母豬所生之小豬及間隔 2 週免疫 2 次之小豬,均可耐過在第五週齡時以強 毒巴氏桿菌之連續攻擊。 |
英文摘要 | From 14 isolated strains Pasteurella multicida, two strains which producted dermonecrotic toxin (DNT) were selected. As the bacteria cultured in brain heart infusion adding 5% serum plus for 20 hours, the harvest was sonicated for DNT. After the protein contain of toxin was determinated, the protein concentration was adjusted to 1 mg per millillter. The minimal necrotizing dose of rough DNT was about 3 ug of protein. The purified DNT from column chromatography could produce dermonecrotic reaction on guinea pig by 6 ng of protein. Rough DNT toxin was inactived with formaldehyde. Toxoid added inactived pasteurella cell suspension was mixed with alum gel adjuvant to form toxoid vaccines. Mouse vaccinated twice with the toxoid vaccines appeared 1.75 to 1.93 log folds of protected potency to the challenge of pathogenic Pasteurella cell suspension. Guinea pigs that had two times immuned with toxoid vaccines showed 75 to 100% protected potency to LD �t bacterial suspension challenge. Pregnant sows at 3 ∼ 5 weeks prior farrowing and piglets at 1 to 3 weeks of age were immuned twice with toxoid vaccines at an interval of 2 ∼ 3 weeks showed completed safety and resulted in protecting the baby pigs and piglets to the challenged at 5 weeks old. |
本系統中英文摘要資訊取自各篇刊載內容。