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題名 | 肥胖婦女減重對其與常見代謝疾病相關之血中指標之影響=Effects of Weight Reduction on Blood Indices Related to Metabolic Disorders in Obese Women |
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作者 | 劉美媛; 葉松鈴; 陳維昭; | 書刊名 | 中華民國營養學會雜誌 |
卷期 | 23:3 1998.08[民87.08] |
頁次 | 頁227-237 |
分類號 | 415.599 |
關鍵詞 | 肥胖; 減重; 血糖; 胰島素; 尿酸; Obesity; Weight reduction; Blood glucose; Insulin; Uric acid; |
語文 | 中文(Chinese) |
中文摘要 | 體重過重或肥胖常與許多慢性疾病的發生或嚴重程度有正相關,而減重可使其疾病症狀減輕或消除。本研究針對肥胖及減重對一些與代謝疾病相關之生化指標做探討。受測者為67個停經前之肥胖女性,依身體質量指數(BMI)26.4-30.8者分為輕度肥胖組,而 BMI>30.8者為中度肥胖組, 以飲食控制方式減輕體重,追蹤半年,取體重減輕量大於原體重5%以上之29人,與年齡身高相當之正常體重者18人組成之控制組互相比較,並探討減重前後血中代謝指標的變化。結果顯示:肥胖者與正常體重者之血漿白蛋白及血比容無差異,血紅素則肥胖者較正常體重者為高,三項指標在減重前後均無顯著差異,顯示低熱量之飲食控制對減重者之一般營養狀況無不良影響。肥胖者肝臟功能不正常之比例遠較體重正常者高,因為血漿天門冬酸轉胺酵素和丙胺酸轉胺酵素肥胖者有一半以上高於正常值(41╱67),而正常體重者則只有16.7%高於正常值(3╱18),但減重並不能使此二種酵素之活性降至正常。血漿尿酸值以中度肥胖者顯著高於輕度肥胖及正常體重者,減重後尿酸值顯著降低但仍較正常體重者為高。空腹血糖濃度在中度、輕度肥胖組及正常體重組間沒有顯著差異,但胰島素濃度則以中度肥胖組高於輕度肥胖組,且輕度肥胖組高於正常體重組(p<0.0001)。減重後空腹血糖及胰島素濃度皆有明顯的下降(p<0.01),血糖可降至正常體重組之水準,但胰島素值則仍較正常體重組為高。葡萄糖耐量試驗方面之結果可見,減重對胰島素濃度並無顯著影響,但120及150分鐘時之血糖濃度則以減重後顯著較減重前低。綜而言之,減重5%以上有降低血漿尿酸、血糖、胰島素值及肥胖所引致之胰島素阻抗性的效應。 |
英文摘要 | Numerous studies demonstrate a positive correlation between chronic diseases and obesity, and weight reduction prevents or ameliorates the presence or the severity of the diseases. This study focused on the effect of weight reduction on the changes of blood indices related to some metabolic diseases. The subjects of this study were 67 premenopause obses women, those with body mass index (BMI) between 26.4 to 30.8 kg/m�� considered as mild obses, and those with BMI > 30.8 kg/m�� as moderately obese. The obese subjects were controlled by a low kcal diet for half a year to lose weight. Twenty-nine women lose 5% of their initial body weight. Changes of blood parameters were measured before and after weight reduction, and 18 age matched normal weight women served as control. The results demonstrated that plasma albumin and hematocrit were not significantly differnet between obese and normal weight groups, hemoglobin was even higher in the obese group than that in normal weight group. No significant differences in plasma concentrations of albumin, hematocrit and hemoglobin were seen before and after weight reduction. This result indicates that low kcal diet intake does not influence the general nutritional status of the obese subjects during weight loss. More than half of the obese women (41/67) had higher plasma asparate aminotranaferase (AST) and alanine aminotransferase (ALT) activities, whereas only 16.7% of the normal weight women (3/18) had abnormal AST, ALT activities. Weight reduction did not normalize the enzyme activities in this study. Plasma uric acid was significantly higher in moderately obese group than that of mildly obese and normal weight groups. No significant difference in fasting blood sugar among mildly, moderately obese and normal weight groups, however, insulin levels were significantly different among the 3 groups, increased in accordance with the degree of obesity (P<0.0001). Weight reduction significantly lowered the plasma glucose, insulin as well as uric acid concentrations (P<0.01), although plasma insulin and uric acid levels were still higher than those in normal weight group. Plasma glucose and insulin response to the glucose tolerance test showed weight reduction had no effect on the decrement of insulin levels. However, plasma glucose levels at 120 and 150 minute were significantly lower after weight reduction than those before weight loss. These results suggest that weight reduction more than 5% of initial body weight significantly lowers plasma concentrations of uric acid, insulin as well as glucose, and insulin resistance induced by obesity is also improved after weight reduction. |
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