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題 名 | Effects of Insulin therapy on Non-Insulin-Dependent Diabetics with Secondary Oral Hypoglycemic Agent Failure=胰島素治療對非胰島素依賴型糖尿病病人併口服降血糖藥物失效之影響 |
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作 者 | 彭雲杏; 莊峻鍠; | 書刊名 | 長庚醫學 |
卷 期 | 21:3 1998.09[民87.09] |
頁 次 | 頁271-276 |
分類號 | 418.271 |
關鍵詞 | 口服降血糖藥物失效; 貝他細胞功能; 升糖素試驗; 胰島素治療; Oral hypoglycemic agent OHA failure; β-cell function; Glucagon test; Insulin therapy; |
語 文 | 英文(English) |
中文摘要 | 背景:為探討非胰島素依賴型糖尿病病人對口服降血糖藥物失效的機轉並瞭解胰 島素治療對這些病人的影響,我們觀察他們的胰臟貝他細胞功能及代謝指標。 方法:我們分析37位非胰島素依賴型糖尿病併口服降血糖藥物失效病人的臨床特徵及其丙- 胜�騛奰R脈升糖素試驗的反應。這些病人均接受胰島素治療,我們追蹤他們 3個月後的空腹 血糖、糖化血色素、身體量質指數、6-12個月後的血清三酸甘油酯及膽固醇變化,及0.5-29個 月後升糖素試驗。 結果:有11位(29.7%)病人貝他細胞功能不良(A組),另外26位(70.3%)病人則為貝他細胞 功能良好(B組)。A組病人較B組的病人為瘦(身體質量指數:18.9��0.7 vs 22.1�� 0.6kg/m��,p=0.006)。經胰島素治療後,整組的病人空腹血糖(215��14 vs 282��12 mg/dL, p<0.001)及糖化血色素(9.2��0.5 vs. 11.6��0.5%,p<0.001)顯著降低而身體質量指數 (23.1��0.7 vs 21.6��0.7 kg/m��,p<0.001)則顯著增加,但血脂及貝他細胞功能並無變化 。有5/6位A組的病人貝他細胞功能仍然不好,然而所有B組病人其貝他細胞功能均維持穩定。 結論:非胰島素依賴型糖尿病併口服降血糖藥物失效的病人中約有三分之一為永久胰島素分 泌不足,這些病人需要接受長期胰島素治療。 |
英文摘要 | Background: To search for the mechanisms of secondary oral hypoglycemic agent (OHA) failure in non-insulin-dependent diabetic (NIDD) and to identify the effects of insulin therapy on these patients, we observed their pancreatic ��-cell function and metabolic parameters. Materials and Methods: The clinical characteristics and C-peptide responses to glucagon were analyzed in 37 NIDD with secondary OHA failure. All patients received insulin therapy and we measured their fasting plasma glucose (FPG), body mass index (BMI) and glycohemoglobin (HbA�甥) levels at 3 months, their serum triglyceride and cholesterol levels at 6-12 months and performed glucagon tests at 0.5-29 months. Results: Poor ��-cell function was observed in 11 (29.7%) patietns (Group A) and fair ��-cell function in 26 (70.3%) patients (Group B). The mean age at diagnosis, the number of years since diagnosis of diabetes, FPG levels and HbA�甥 levels were similar in both groups. However, the patients in Group A had a lower average BMI (18.9��0.7 vs 22.1��0.6kg/m��,p=0.006) than those of Group B. After insulin theraay, the FPG levels (215��14 vs 282��12 mg/dL,p<0.001) and HbA�甥 levels 9.2��0.5 vs 11.6��0.5%, p<0.001) of both groups decreased but the BMI (23.1��0.7 vs 21.6��0.7 kg/m��,p<0.001) increased significantly. However, the blood lipid levels and ��-cell function did not change. The ��-cell function was still poor in 5 out of 6 patients in Group A, but it was unchanged in all patients in Group B. Conclusion: About 1/3 of NIDD with secondary OHA failure are permanently insulin deficient and need long-term insulin treatment. |
本系統中英文摘要資訊取自各篇刊載內容。