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題名 | High-Grade Endometrial Stromal Sarcoma in a 10-Year-Old Girl: Case Report=十歲小女孩之高度惡性子宮膜基質肉瘤:病例報告 |
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作者 | 王國楨; 梁德城; 蘇聰賢; 洪芳宜; 楊育正; Wang, Kuo-chen; Liang, Der-cherng; Su, Tsung-hsein; Hung, Fang-yi; Yang, Yuh-cheng; |
期刊 | 長庚醫學 |
出版日期 | 19980900 |
卷期 | 21:3 1998.09[民87.09] |
頁次 | 頁312-317 |
分類號 | 417.281 |
語文 | eng |
關鍵詞 | 子宮內膜基質肉瘤; 小孩; 青少年; Endometrial stromal sarcoma; Child; Adolescence; |
中文摘要 | 子宮內膜基質肉瘤主要發生在停經後婦女,很少發生在孩童時期。本文報導一位 罹患高度惡性子宮內膜基肉瘤的10歲小女孩,最初主訴解小便時下腹疼痛,病人尚未有初經 且無陰道出血,住院接受剖腹探查手術顯示子宮癌瘤併侵犯骨盆腔,因此進行以下手術:全 子宮切除、雙側卵巢切除、骨盆腔淋巴節切片及大網膜部分切除。手術後追加放射線治療及 口服黃體素治療、惡性子宮內膜基質肉瘤是很罕見的疾病,尤其是孩童及青春期的女孩更少 ,診斷上甚至比停經後婦女更難。由於病例數少,至今仍少有大型臨床研究來找出有效的治 療方法。手術切除是最基本的治療,手術後放射線治療對骨盆腔區域復發的控制有幫助,因 為預後很差,所以復發後的治療原則除了考慮到療效以外也要顧及病人的生活品質。九個月 後癌瘤復發併肝轉移,病人此時接受口服化學藥物 etoposide療程,此種延長式口服化學治 療投與簡單且病人遵囑性(compliance)良好,使病情穩定達4個月。 |
英文摘要 | Endometrial stromal sarcomas occur primarily in perimenopausal women and quite uncommon in children. We report a case of high-grade endometrial stromal sarcoma in a 10-year-old girl, who initially experienced lower abdominal pain on voiding. After a series of examinations, surgical treatment was performed, including an extended total hysterectomy with bilateral salpingo-oophorectomy, bilateral pelvic lymph node sampling, and partial omentectomy. Adjuvant radiotherapy and hormonal therapy followed, however, the abdominal tumor recurred 9 months later. Invasion of the right lobe of the livr with compression of the inferior vena cava and pleural effusion was noted. The patient then received prolonged oral etoposide therapy. The treatment stabilized the tumor size and relieved her symptoms for 4 months. She finally succumbed to the disease as a result of distant metastasis. |
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