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題 名 | Lofexidine對海洛因戒斷症狀之治療效果: 一開放性試驗=Lofexidine in the Treatment of Heroin Withdrawal: An Open Trial |
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作 者 | 林式穀; 張良慧; 陳建煒; 簡錦標; | 書刊名 | 臺灣精神醫學 |
卷 期 | 12:1 1998.03[民87.03] |
頁 次 | 頁36-44 |
分類號 | 415.8753 |
關鍵詞 | 鴉片類藥物成癮; 解毒; 低血壓; Opioid dependence; Detoxification; Lofexidine; Hypotension; |
語 文 | 中文(Chinese) |
中文摘要 | 目的:Lofexidine是一種clonidine類構物,在臨床上與clonidine類似有減緩鴉片類 藥物成癮戒斷之作用,但是對於降低血壓的作用較不顯著,可高劑量使用而不造成姿勢性低 血壓。本研究比較於海洛因成癮戒斷時,使用lofexidine與否對戒斷症候群之療效。方法:本 研究採開放式比較性試驗,共42位海洛因成癮住院解毒病人(男/女:32/10),平均年齡約 32.9±5.9歲;體重:59.9±9.5公斤;海洛因使用時間:3.8±3.8年。在一般處理戒斷的症狀控制藥物 治療之外,隨機給予lofexidine共21位病人為研究組,另21位未給予lofexidine為對照組。 Lofexidine最高使用劑量每天1.6mg。以戒斷症狀量表每天三次評估,每天四次服藥前皆記錄 其血壓。結果:研究組的戒斷症狀在第二至第四天顯著低於對照組,單項戒斷症狀出現頻率之 比較以肌肉酸痛及背痛改善最多。研究組平均血壓較對照組降低5-10 mmHg。結論:lofexidine 的確會減輕鴉片類藥物成癮之戒斷症狀,血壓降低之副作用輕微,故建議可於海洛因成癮患 者門診解毒使用。 |
英文摘要 | Objective: Lofexidine is an analogue of the receptor agonist clonidine, which is effective in the amelioration of opioid withdrawal symptoms. But the clinical application of clonidine, especially in outpatients, has been limited due to its marked hypotensive effects. Reports from preliminary open studies have suggested that lofexidine is at least as effective as clonidine in the management of opioid withdrawal symptoms, without producing the same side effects. In this open trial, we studied the effectiveness of lofexidine and supportive treatment in heroin withdrawal, and compared the results with those obtained from supportive treatment alone. Methods: Forty-two hospitalized heroin addicts (male/female: 32/10; age: 32.9 ± 5.9 yrs; body weight: 59.9 ± 9.5 Kg; duration of addiction: 3.8 ± 3.8 yrs) managed by supportive therapy, were randomly assigned to lofexidine and control group. The maximum daily dose of lofexidine was 1.6 mg. The abstinence symptom rating scale (ASRS) was used three times a day to monitor patients for the presence of opiate withdrawal syndrome. Blood pressure was checked four times a day before medication. Results: There was no significant difference in demographic data between the two groups. From the second to the fourth day of the withdrawal period, ASRS scores were significantly lower in the lofexidine group. Withdrawal symptoms of back pain and muscular cramp were markedly improved after lofexidine treatment. Mean systolic and diastolic blood pressure decreased by 4.6/0.6 mmHg in the lofexidine group, which was not clinically significant. Conclusion: The findings of this study suggest that lofexidine is an effective treatment for heroin withdrawal syndrome, the side effects of lofexidine treatment were sufficient1y mild to allow treatment in an outpatient setting. (Full Text in Chinese) |
本系統中英文摘要資訊取自各篇刊載內容。