查詢結果分析
相關文獻
- Interaction of Norfloxacin with Phospholipids in Liposomes and Their Stability
- 天然抗氧化劑之添加對花生油安定性之探討
- α-生育醇和磷脂質對大豆純化油的抗氧化作用
- Adhesion and Adsorption of High Energy Wetting Colloids on Low Energy Polymers: Interfacial Thermodynamics versus Electrostatic Interactions
- 藥物代謝、交互作用與副作用
- 木材之化學改質及其膠合性之研究(1)--醚化處理對木材尺寸安定性及力學性質之影響
- 葛拉絲颱風(1994)及其受到臺灣地形影響之研究 第二部份:數值模擬
- 幾丁聚醣在海綿蛋糕製作上的應用
- 蒸煮及鹽酒的添加對魚肉脂肪酸組成及脂質安定性之影響
- Information Asymmetry and Its Interaction with Budgetary Participation and Budgetary Emphasis on Budgetary Slack: Additional Evidence
頁籤選單縮合
題名 | Interaction of Norfloxacin with Phospholipids in Liposomes and Their Stability=微脂粒中Norfloxacin與磷脂質的交互作用及其安定性 |
---|---|
作者 | 林恆弘; 許立人; 王四切; 蔡義弘; | 書刊名 | 嘉南學報 |
卷期 | 24 1998.11[民87.11] |
頁次 | 頁86-94 |
分類號 | 418.1 |
關鍵詞 | 磷脂質; 交互作用; 安定性; Norfloxacin; Liposome; Conformational analysis; DSC; Stability; |
語文 | 英文(English) |
中文摘要 | 本研究是採用兩種製造過程將 norfloxacin 包埋於微脂粒中,再以熱分析儀與構 造分析來探討 norfloxacin 與微脂粒中之磷脂質的交互作用; 至於微脂粒包覆型藥物之長 期安定性,則是藉由在不同的貯存條件下,檢測 norfloxacin 的滲漏情形。 上述實驗的結 果指出,微脂粒若採行併合乙醇注入與冷凍乾燥的製程,norfloxacin 不僅會包覆於微脂粒 的內部空腔中,同時也常會包埋於脂質雙層的分子內,進而提升了微脂粒之藥物的包覆率; 為了長期的安定性,本研究建議,微脂粒應以凍晶乾燥之粉體在較低溫度下進行貯存,使用 前再加入二次蒸餾水還原。 |
英文摘要 | Two perparation procedures were carried out to encapsulate norfloxacin into liposomes. The interaction of norfloxacin with phospholipids in liposomes was investigated by using differential scanning calorimetry and conformational analysis. The long term stability of liposomal drug was studies by measuring the leakage of norfloxacin at various storage conditions. These results indicated that, for liposomes prepared through the ethanol injection and freeze-drying processes, norfloxacin was not only encapsulated within the liposomes cavity but also bound to the lipid bilayer. Thus, the drug encapsulation inside liposomes was increased. For the long term stability, the results suggested that liposomes should be stored in the state of lyophilized powder at lower temperature and reconstitute by adding double- distilled water before used. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。