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題 名 | Effects of Thrombin on the Growth, Protein Synthesis, Attachment, Clustering and Alkaline Phosphatase Activity of Cultured Human Periodontal Ligament Fibroblasts=凝血酶對培養之牙周膜造纖維細胞之生長、間質蛋白合成、細胞附連能力、聚集以及鹼性磷酸酶活性之影響 |
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作 者 | 陳朝寶; 林俊彬; 張美姬; 謝季全; 許勝傑; 林建良; 鄭景暉; | 書刊名 | Proceedings of the National Science Council : Part B, Life Science |
卷 期 | 22:4 1998.10[民87.10] |
頁 次 | 頁137-143 |
分類號 | 416.946 |
關鍵詞 | 凝血酶; 牙周膜; 纖維細胞; 蛋白質; 合成; 細胞生長; 牙周治療; 傷口修復; Cell clustering; Cell growth; Periodontal ligament fibroblasts; Protein synthesis; Thrombin; Wound healing; |
語 文 | 英文(English) |
英文摘要 | Previous studies have indicated that thrombin can activate pulp cells, including fibroblasts. Because pulp cells and periodontal ligament (PDL) fibroblasts can express thrombin receptor mRNA, the specific aim of this study was to determine whether thrombin can activate the growth, attachment, protein synthesis, alkaline phosphatase activities and cellular clustering of cultured human PDL fibroblasts. Thrombin can stimulate the growth of PDL fibroblasts in a dose dependent manner (as analyzed by MTT assay). At concentrations of 5 and 10 U/ml, thrombin increased the cell numbers to 141% and 153% greater than that of the control after 5 days of incubation, respectively. Thrombin (5-20 U/ml) also stimulated the protein synthesis rate (assayed by [3H]proline incorporation) to 1.88-2.13 fold that of the control. However, pretreatment of PDL fibroblasts with thrombin (1-20 U/ml) could not promote the attachment of PDL fibroblasts to type I collagen and fibronectin. Moreover, thrombin could induce clustering of PDL fibroblasts within a concentration range of 5-20 U/ml. However, thrombin (1-20 U/ml) exerted neither stimulatory nor inhibitory effect on cellular alkaline phosphatase activities. In conclusion, it appears that the presence of thrombin seems to have effects on PDL fibroblasts in terms of cell growth, protein synthesis and cell clustering. This suggests that thrombin might be important in the early healing process of periodontium following periodontal surgery. |
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