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相關文獻
- Pathology of Hepatolithiasis
- Histomorphometric Evaluation of Mucin Content in Stone-Containing Intrahepatic Bile Ducts
- 再論肝內結石與肝管癌
- 肝葉切除術以治療左肝內結石症
- Choledochoscopic Heat-Probe Therapy: An Adjunctive Palliative Treatment for Intrahepatic Cholangiocarcinoma With Hepatolithiasis
- 照顧一位肝內結石的護理經驗
- Changes of Intrahepatic Ducts Before and after Removal of Intrahepatic Stones
- 肝內結石合併膽管狹窄之治療
- Silver-Binding Nucleolar Organizer Regions in Hepatolithiasis and Bile Duct Cancer
- 複雜性兩側狹窄性肝內結石症之治療
頁籤選單縮合
題名 | Pathology of Hepatolithiasis=肝內結石症之病理學所見 |
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作者 | Nakanums,Yasuni; Harada,Kenichi; Sasaki,Motoko; Tsuneyama,Koichi; | 書刊名 | 中華民國外科醫學會雜誌 |
卷期 | 31:1 民87.01-02 |
頁次 | 頁1-8 |
分類號 | 415.53 |
關鍵詞 | 肝內結石; Hepatolithiasis; |
語文 | 英文(English) |
英文摘要 | Pathological features of the stone-bearing intrahepatic bile ducts in hepatolithiasis, are reviewed with an emphasis on the mucin profile and bile duct fibrogenesis. A majority of stones in this disease are calcium-bilirubin stones, while cholesterol stones are also increasing in Japan. The affected intrahepatic bile ducts bearing the former stones are fibrotic and their lumen shows alternative dilatation and stenosis. Histopathologically, the affected bile ducts show chronic cholangitis with hyperplasia of the intrahepatic peribiliary glands and biliary lining epithelia, bile duct fibrosis and nonspecific inflammatory cell infiltration in a variable combination (chronic proliferative cholangitis). Biliary mucosa of the stone-containing ducts show mucus gland hyperplasia resembling pseudopyloric gland hyperplasia and mucin phenotypes compatible with gastric mucosa. These glands and also the hyperplastic surface epithelia secrete much acid and neutral mucin. Peribiliary mast cells expressing fibrogenic factors such as basic fibroblast growth factor and histamine may be significantly involved in bile duct and periductal fibrosis. infrequently, this disease is associated with cholangiocarcinoma which develops through a multi-steps process. Sequential phenotypic changes during carcinogenesis are being evaluated, although an underlying genetic alterations remain unclarified. It is important to evaluate the mechanism and process of stone formation, biliary fibrosis and carcinogenesis in hepatolithiasis by the modern technology available. |
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