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相關文獻
- Silver-Binding Nucleolar Organizer Regions in Hepatolithiasis and Bile Duct Cancer
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- Intrahepatic Stones--A Review
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頁籤選單縮合
題名 | Silver-Binding Nucleolar Organizer Regions in Hepatolithiasis and Bile Duct Cancer=肝內結石與膽管癌之銀染核仁區之研究 |
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作者 | 柯成國; | 書刊名 | Proceedings of the National Science Council : Part B, Life Science |
卷期 | 21:2 1997.04[民86.04] |
頁次 | 頁43-48 |
分類號 | 416.246、416.246 |
關鍵詞 | 肝內結石; 膽管癌; 銀染核仁區; Hepatolithiasis; Cholangiocarcinoma; Nucleolar organizer regions; |
語文 | 英文(English) |
中文摘要 | 肝內結石症及膽管癌之關連是一直被認為有關的,在肝內結石症之膽管表皮細胞 增生變化是常見的。本研究是將肝內結石症( 21 例)、肝內結石症合併膽管癌( 14 例) 及肝內結石切除標本無膽石膽管( 11 例)做為對照組,各組標本染出細胞核仁區來計算核 仁數且以判定其增生程度。核仁區可分成點狀型及結合型二種。點狀型計算數目,但結合型 計算含此型之百分比。 在肝內結石病例:膽管內腺體及膽管外腺體之核仁數分別為 2.7 ± 1.2 (M ± SD) and 3.6 ± 1.2,而膽管癌細胞數目為 4.7 ± 2.4 之明顯增加,而且結合 型占有 28.1 ± 4.4 %,遠高於膽管表皮而與膽管外腺體相近。 因此經這研究我們認為增 生癌化因素可能源由膽管表皮或膽管內腺體產生,而膽管表皮及膽管內腺體雖易接觸感染性 膽汁及膽石之物性刺激,但較易脫落,所以實際癌化之病巢可能在膽管外腺體群,因其核仁 變化與癌細胞群相近。結論,肝內結石會形成膽管癌可能性相當可信,尤甚是膽管外腺體群 ,因此在治療上必須更加注意。 |
英文摘要 | Hepatolithiasis and bile duct cancer have usually been linked together especially in Asian countries. Epithelium cells of bile duct or ductal glands had proliferative changes in patients with hepatolithiasis usually. The numbers and shape of the nucleoli were studied with special staining of AgNOR (Nucleolar Organizer Regions) on bile ducts without calculi (n=11), with calculi (n=21), and hepatolithiasis with bile duct carcinoma (n=14). The patterns of AgNOR were classified into a dotted type and a cluster type under light microscopic examination. AgNORs scores were found to be 2.7 ± 1.2 (M ± SD) and 3.6 ± 1.2 for intramural glandular cells and extramural glandular cells in hepatolithiasis (p < 0.05). In the cases of bile duct carcinoma, the percentage of the cluster form of AgNOR was 28.1 ± 4.4 %, and the scores were 4.7 ± 2.4 for bile duct cancer, which was significantly different from intramural glands, but not different from the extramural glands in hepatolithiasis. High scores of the dotted type and high percentage of cluster type have high potentiality of malignant changes. From this study, unknown substances for malignant transformation might be secreted from the inner epithelium and or intramural glandular epithelium both of which are usually in contact with the infected bile and have chronic irritation from the stones. Extramural glands of the bile duct had higher potential for proliferation or malignant transformation in our study. Hence, longterm follow-up study of those patients with hepatolithiasis should be done very carefully especially due to the possibility of a combination of neoplastic changes in hepatolithiasis. |
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