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相關文獻
- Hepatitis E in India
- 旅遊與A型、E型肝炎的防治
- E型病毒性肝炎最新進展
- Polymerase Chain Reaction Analysis for Viral Nucleic Acids in Acute Sporadic Hepatitis Patients Negative for Serum Hepatitis B Surface Antigen and Antibodies to Hepatitis C Virus
- A型肝炎之今昔--兼談E型肝炎
- 禽類E型肝炎病毒與雞的肝炎巨脾症或巨肝脾病
- 禽類E型肝炎病毒與雞的肝炎巨脾症或巨肝脾病
- E型肝炎
- E型肝炎的新觀念
- 急性E型肝炎
頁籤選單縮合
題名 | Hepatitis E in India=印度之E型肝炎 |
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作者姓名(外文) | Tomar,Balvir S.; | 書刊名 | 中華民國小兒科醫學會雜誌 |
卷期 | 39:3 民87.05-06 |
頁次 | 頁150-156 |
專輯 | 病毒性肝炎 |
分類號 | 415.5332 |
關鍵詞 | E型肝炎; Hepatitis E; Genetic diversity; New epidemiological data; |
語文 | 英文(English) |
英文摘要 | Institute of Pediatric Gastroenterology is superspecialised referral institute for all Pediatric Gastroenterological diseases from all over the country and for adjoining countries. We have our data and experience on 10,500 cases of proven Hepatitis E (HEV) in Pediatric population. HEV is non-enveloped 27-30 nm diameter RNA virus, prototype for α -like supergroup of positive stranded RAN virus. Indian HEV strain has 97% nucleotide and 98% amino acid sequence identity with Chinese strains but much diversity with Mexican strain. More than 70% acute hepatitis occurring in Pediatric population in this subcontinent are caused by HEV and 80% of these are sporadic. 90% cases were enterically transmitted, spread primarily by fecally contaminated drinking water (70%) and by food (20%), in 9.5% case spread probably was because of person to person and household contact. We could demonstrate HEV in urine, respiratory secretions. Interestingly we found HEV in insects like Flies, Cockroaches, and also in engorged Bedbugs and in Mosquitoes, apart from briefly boiled Mussels, and partially cooked cockles. Maternal-neonatal transmission could be seen if mother had HEV infection in third trimester of pregnancy. In 5 cases we could demonstrate HEV in breast milk. By studying on 10 volunteers, 40% have anicteric form only accompanied by anorexia, epigastric pain. HEV appeared in serum before the icteric phase. Shedding of virus in stool starts before the icteric phase and continued during the high levels of abnormal ALT. Hepatitis IgG anti-HEV persist up to 4 years. In 5 cases we could establish Transfusion associated Hepatitis (TAH). No chronicity could be documented. 5% cases had fulminant viral Hepatitis (FVH)/Sub fulminant viral hepatitis (SVH), α -interferon (IFN) has been proved beneficial in these cases, further use of intravenous PGEI could also be beneficial. Inadequate chlorination of drinking water was an important additional factor for causing epidemics. A free residual chlorine concentration of at least 0.5 mg/l for minimum of 30 minutes is considered adequate as quality of drinking water. |
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