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頁籤選單縮合
題名 | Polymorphisms of the Apolipoprotein B3' Variable Number of Tandem Repeats Region Associated with Coronary Artery Disease in Taiwanese=B形表面脂蛋白基因3'端重複區的多形現象與臺灣冠心症病人關聯性的研究 |
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作者 | 潘如濱; 姜安娜; 周嘉裕; 陳雲亮; 戴政; | 書刊名 | 臺灣醫學會雜誌 |
卷期 | 97:4 1998.04[民87.04] |
頁次 | 頁233-238 |
分類號 | 415.31 |
關鍵詞 | B形表面脂蛋白; 基因; 冠心症病人; ApoB gene; Coronary artery disease; Polymerase chain reaction; Dyslipidemia; Variable number of tandem repeats; |
語文 | 英文(English) |
英文摘要 | We studied the allelic frequency of the variable number of tandem repeats region 3' of the apolipoprotein B gene (apoB 3' VNTR) and its impact on coronary artery disease (CAD) in 150 patients with CAD and 153 normal controls in a Taiwan population. apoB 3' VNTR alleles were classified according to the number of repeats of a 15-bp hypervariable element (HVE), the sequence of which was determined using the polymerase chain reaction and direct sequencing. Thirteen alleles comprising from 26 to 54 HVEs were identified. The CAD patients had greater heterozygosity (0.58 vs 0.42) and a higher frequency of long (> 36-HVE) apoB 3' VNTR alleles than the controls (18.7% vs 10.8%, p 0.01). CAD patients with two HVE-36 alleles and no HVE-32 alleles (the two most common forms) had significantly higher concentrations of LDL-cholesterol. apolipoprotein B, and triglycerides, and significantly lower values of HDL-cholesterol, and apolipoprotein AI than the control group (p < 0.01 for all comparisons). The length of the apoB 3' VNTR was not correlated with the plasma concentrations of any of the lipids. We conclude that long apoB 3' VNTR alleles occur more frequently in CAD patients, but that apoB 3' VNTR genotypic variation has little impact on the risk of dyslipidemia in Taiwanese. |
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