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題名 | Effect of Arginine Vasopressin on Magnesium Handling in Rat Remnant Kidneys=抗利尿素影響尿毒症鼠腎臟排泄鎂之研究 |
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作 者 | 楊志剛; 曾淑汝; 陳世明; | 書刊名 | 中華民國腎臟醫學會雜誌 |
卷期 | 11:2 1997.06[民86.06] |
頁次 | 頁71-77+110 |
分類號 | 415.1461 |
關鍵詞 | 腎臟切除; 尿毒症; 鎂; 鎂排泄分數; Nephrectomy; Uremia; Tubular reabsorption; Magnesium; Arginine vasopressin; |
語文 | 英文(English) |
中文摘要 | Renal handling of magnesium (Mg) was investigated in normal, uninephrectomized (UNX), and fivesixths nephrectomized (5/6NX) uremic rats in both conscious and anesthetic conditions. The filtered Mg load decreased whereas both urinary Mg excretion and fractional Mg excretion (FEMg) increased in 5/6NX rats, indicating the decrease of tubular Mg reabsorption with uremia. Arginine vasopressin (AVP) in an antidiuretic dose increased FEMg significantly in normal and UNX rats hut not in 5/6NX uremic rats. Moreover, FEMg correlated positively with urine flow rate and negatively with creatinine clearance. It is concluded that decreased tubular Mg reabsorption in 5/6NX uremic rats might partly result from increment of urine flow rather than from increased secretion of AVP. |
英文摘要 | Renal handling of magnesium (Mg) was investigated in normal, uninephrectomized (UNX), and fivesixths nephrectomized (5/6NX) uremic rats in both conscious and anesthetic conditions. The filtered Mg load decreased whereas both urinary Mg excretion and fractional Mg excretion (FEMg) increased in 5/6NX rats, indicating the decrease of tubular Mg reabsorption with uremia. Arginine vasopressin (AVP) in an antidiuretic dose increased FEMg significantly in normal and UNX rats hut not in 5/6NX uremic rats. Moreover, FEMg correlated positively with urine flow rate and negatively with creatinine clearance. It is concluded that decreased tubular Mg reabsorption in 5/6NX uremic rats might partly result from increment of urine flow rather than from increased secretion of AVP. |
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