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題名 | Photodynamic Therapy for Facial Squamous Cell Carcinoma in Cats Using Photofrin=光照療法及光顯劑治療貓表皮鱗狀上皮癌 |
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作者姓名(中文) | 張承仁; 賴永隆; 翁昭仁; | 書刊名 | 臺北市獸醫師公會會刊 |
卷期 | 16:1 1998.03[民87.03] |
頁次 | 頁1-7 |
分類號 | 437.24 |
關鍵詞 | 光照療法; 光顯劑; 新血紫衍生物; 鱗狀上皮癌; Photodynamic therapy; Photosensitizer; Photofrin; Squamous cell carcinoma; |
語文 | 英文(English) |
中文摘要 | 背景:光照療法(photodynamic therapy)已被證實對如位於皮膚、呼吸、消化道 及泌尿生殖系統之表面惡性腫瘤俱療效。本研究主要在評估新的光顯劑(photosensitizer) --Photofrin�飽A對於治療貓表皮鱗狀上皮癌(squamous cell carcinoma)之安全性及其 功效;以期為人體治療之借鏡。貓因於自然發生之表皮鱗狀上皮癌為研究對象。 方法:於靜脈注射光顯劑,48小時後用 argon-pumped dye laser 照射做光照療法。治療後 評估其完全反應率、局部控制間期。 結果:8例腫瘤為T1a, 9例為T1b,14例為T2b。於期數觀點,完全反應率及局部控制間期之 結果俱統計學意義(p<0.0001)。光顯劑於注射後無臨床上、血液學及生化學之毒性反應 。 結論:光顯劑配合光照療法對於治療早期貓表皮鱗狀上皮癌乃為安全有效療法之一。 |
英文摘要 | Background:Photodynamic therapy (PDT) has been shown to be an effective treatment modality for surface-oriented neoplasms of the skin, respiratory, gastrointestinal, and urogenital systems. The purpose of our study was to assess the safety and efficacy of PDT using Photofrin�� in the treatment of squamous cell carcinomas of feline facial skin. Materials and Methods: Cats with naturally occurring squamous cell carcinomas of the skin were entered into the study. PDT was delivered to the tumors using an argonpumped dye laser 48 hours after the administration of the photosensitizer porfimer sodium (Photofrin��). following treatment, the tumors were evaluated for complete response rates and local control durations. Results: Eight tumors were staged T1a, 9 staged T1b, and 14 staged T2b. Complete response rates as well as local control durations were significantly related to stage (p<0.0001). Complete response was achieved in 100% of the T1a tumors and 53% of the T1b tumors; the overall 1-year local control rate for all treated tumors was 62% Clinical, hematological, and biochemical evidence of toxicity was not seen in any cat following drug administration. Conclusion: PDT with the photosensitizer Photofrin�� was safe and effective in treating early stage squamous cell carcinomas of the feline skin. |
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