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題 名 | Cardiac Hemodynamic Effects of Ethanol in Chinese Men with Different Alcohol and Aldehyde Dehydrogenase Genotypes=不同醇及醛脫氫酶基因型男性國人的酒精之心臟血液動力效應 |
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作 者 | 曹殿萍; 彭家勛; 王明芳; 蕭海松; 林棟樑; 陳瑞香; 陳慧君; 江樵熹; 尹士俊; | 書刊名 | Acta Cardiologica Sinica |
卷 期 | 14:1 民87.01-03 |
頁 次 | 頁1-8 |
分類號 | 414.41 |
關鍵詞 | 醇和醛脫氫酶; 基因型; 乙醇; 乙醛; 心臟血管效應; Alcohol and aldehyde dehydrogenase; Genotype; Ethanol; Acetaldehyde; Cardiovascular response; |
語 文 | 英文(English) |
中文摘要 | 背景:醇脫氫□(ADH)和醛脫氫□(ALDH)是人類乙醇代謝的主要□系統。東方人ADH及ALDH 的對偶基因變異會影響其飲酒行為及酒癮發生。本研究的目的探討不同ADH2及ALDH2對偶基因型之健康男性國人於飲中劑量酒精後,他們血中乙醇和乙醛的濃度變化及與血流動力效應的關係。 方法:ADH2,ADH3和ALDH2的對偶基因型以聚合□連鎖反應及限制□片斷長度多型性鑑定。血中乙醇和乙醛濃度分別應用氣相及高壓液相層析法測定。心臟血流動力效應以杜蔔勒超音波測量。 結果:具ADH2*2/*2和ALDH2*1/*1對偶基因型的人,於飲乙醇(0.5克/公斤)40分鐘後,其血中乙醇濃度顯著低於具ADH2*1/*1和ALDH2*1/*1對偶基因型的人及具ADH2*2/*2和ALDH2*1/*2對偶基因型的人,這表示前者體內有較快的酒精代謝。ALDH2異型接合子的人於飲酒後130分鐘,血中乙醛濃度仍遠高於正常ALDH2同型接合子的人。這項觀察與文獻報告突變型ALDH2*2對偶基因為顯性的結果一致。前者之心跳速度和通過僧帽瓣之血流速度於飲酒後70分鐘期間均高於後者。 結論:ALDH2異型接合子的人飲中劑量酒精會造成血中乙醛濃度升高,引發持續不愉快的心臟血管效應,可防止過量飲酒,因而降低其酒精成癮的危險率。 |
英文摘要 | Background. Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) ane the major enzymes responsible for ethanol metabolism in humans. Genetic variation at both the ADH and ALDH loci influences drinking behavior and the development of alcoholism among Orientals. The purpose of this study was to determine hemodynamic effects in healthy Chinese men with different ADH2 and ALDH2 genotypes in relation to their blood ethanol and acetaldehyde levels after a moderate dose of alcohol. Methods. Allelic types of the ADH2, ADH3 and ALDH2 loci were determined by using polymerase chain reaction-directed mutagenesis and restriction fragment length polymorphism. Blood ethanol and acetaldehyde concentrations were determined by head-space gas chromatography and high-performance liquid chromatography with fluorescence detection, respectively. Cardiac hemodynamic responses were measured by using a Doppler echocardiography. Results. At 40 min following ingestion of ethanol (0.5g/kg), subjects with the ADH2*2/*2 and ALDH2*1/*1 genotype showed a significantly lower ethanol level than did the subjects of the ADH2*1/*1 and ALDH2*1/*1 genotype and of the ADH2*2/*2 and ALDH2*1/*2 genotype, suggesting a faster alcohol metabolism. Up to 130 min after ingestion, ALDH2 heterozygotes exhibited considerably greater blood acetaldehyde levels than those of the normal ALDH2 homozygotes, irrespective of the ADH2 allelic variance. This is consistent with dominance of the mutant ALDH2*2 allele over the loss of enzyme activity. The ALDH2 heterozygotes showed significantly increased heart rate and blood velocity through mitral valves compared with the normal ALDH2 homozygotes, during 70 min after alcohol intake. Conclusions. Persistent unpleasant cardiovascular effects caused by blood acetaldehyde buildup may prevent ALDH2 heterozygotic persons from excessive drinking, thus reducing their risk of development alcoholism. |
本系統中英文摘要資訊取自各篇刊載內容。