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題 名 | Effects of Insulin on Protein Phosphorylation and Protein Kinase C Activity in Human Malignant Gliomas=胰島素對於人類惡性神經膠質瘤細胞蛋白質磷酸化及Protein Kinase C活性之影響 |
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作 者 | 楊倍昌; 陳榮富; 邱仲慶; 張文昌; 林銘德; 林秀娟; | 書刊名 | Proceedings of the National Science Council : Part B, Life Science |
卷 期 | 22:1 1998.01[民87.01] |
頁 次 | 頁22-30 |
分類號 | 415.114 |
關鍵詞 | 胰島素; 人類惡性神經膠質瘤細胞; 蛋白質磷酸化; Glioma; Insulin; Protein phosphorylation; Protein kinase C; |
語 文 | 英文(English) |
中文摘要 | 為探討人類惡性神經膠質瘤細胞生理功能改變之情形, 本研究以胰島素之訊號傳 遞反應為對象。結果發現胰島素會降低人類惡性神經膠質瘤細胞 serine/threonine 蛋白質 磷酸化反應: 但是在體外培養之正常神經膠質細胞,胰島素則有增強蛋白質磷酸化反應之作 用。此種蛋白質磷酸化反應之改變僅見於神經膠質瘤細胞,而腦膜瘤及許旺氏瘤細胞則無此 反應。 此外,當我們測定細胞中之 Protein Kinase C ( PKC )酵素活性時,發現於胰島 素存在之狀況下,其中一株惡性神經膠質瘤細胞之 PKC 酵素活性總量有明顯的增加; 我們 並利用 PKC 亞型抗體,證實增加活性的為 PKC α, β, δ, ε及γ亞型。但是神經膠質瘤 細胞質內之 PKC- γ及細胞膜上之 PKC- ε個別之活性則受到抑制。本研究證實人類惡性神 經膠質瘤細胞對於胰島素之訊號傳遞反應與正常神經膠質細胞不同。 |
英文摘要 | Modulation of protein phosphorylation activities by insulin was investigated in glioma and normal glial cells. Insulin suppressed the in vitro protein phosphorylation of glioma cells in a dose-dependent manner while it stimulated that of meningiomas, neurilemmomas and glial cells. Although gliomas and glial cells contained different species of tyrosyl phosphoproteins before treatment, they expressed similar kins of tyrosyl phosphoproteins in response to insulin. Insulin increased the avtivities of casein kinase Ⅱ and total protein kinase C (PKC) in glioma and normal glial cells. The membrane-bound PKC activity in U373-MG cells was elevated by insulin. The PKC isozymes, including subtypes α, β, δ, ε and γ, were detected in gliomas, but few were found in glial cells. Insulin down regulated the cytosolic PKC- γ and the membrane-bound PKC- ε proteins in glimas. These results indicate that an altered insulin signaling pathway exists in human gliomas, which might involve differential regulation of PKC isozymes. |
本系統中英文摘要資訊取自各篇刊載內容。