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題名 | Free Radicals, Atherosclerosis, and Development of Antioxidants as Antiatherogenic Agents=自由基、動脈粥狀硬化與發展抗氧化劑為抗動脈硬化劑 |
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作者 | 林怡玲; 邱莉莉; 吳懿哲; 蕭明熙; | 書刊名 | 食品科學 |
卷期 | 24:6 1997.12[民86.12] |
頁次 | 頁690-705 |
專輯 | 「張駟祥教授紀念研討會--食品之保健功效」研討會論文專輯 |
分類號 | 364.64 |
關鍵詞 | 動脈粥狀硬化; 氧化態低密度脂蛋白; 抗氧化劑; Atherosclerosis; Oxidized LDL; Antioxidants; |
語文 | 英文(English) |
中文摘要 | 近年來的研究顯示,動脈粥狀硬化分子的病因形成涉及血管內皮細胞功能變異,單核細胞滲入並被活化成巨噬細胞及平滑細胞增生。低密度脂蛋白的氧化修飾則扮演著一個啟動和促進動脈粥狀硬化和相關的心血管疾病的角色。能抑制低密度脂蛋白氧化的抗氧化劑可能減退動脈粥狀硬化的進展。低密度脂蛋白粒子的構型和其所含的多元不飽和脂肪酸及α-生育酚都是影響其在活體和離體情況下氧化敏感度的重要因素。目前已知一些源自活血化瘀的中藥和食物中的某些植物天然物可抑制低密度脂蛋白氧化,且可推論這些脂溶性抗氧化劑若能箝入低密度脂蛋白粒子,且使其可抗氧化官能基暴露於低密度脂蛋白所含多元不飽和脂肪酸的二雙烯位置之前,則可有利於發揮抗氧化效果。在病理動物模式上,本文亦討論除了紐西蘭兔與WHHL兔之外,脂蛋白妧E缺陷小鼠亦為另一新的動脈粥狀硬化動物模式,可用於評估抗氧化劑的抗動脈硬化效果。本文亦略述及一些源自食物的抗氧化劑在預防心血管疾病的潛力。 |
英文摘要 | Many recent studies have demonstrated that the molecular pathogenesis of atherosclerosis involves endothelial dysfunction, monocyte infiltration, activation of monocytes into macrophages, and smooth muscle cell proliferation. Oxidative modification of low density lipoprotein (LDL) plays a key role in the development of atherosclerosis and coronary heart disease (CHD). Antioxidants capable of inhibiting LDL oxidation may reduce atherosclerosis. The structure and contents of polyunsaturated fatty acids (PUFA) and a-tocopherol are important factors affecting the oxidative susceptibility of LDL in vitro and in vivo. Several antioxidants from traditional Chinese herbs on blood stasis and dietary phytochemicals capable of inhibiting LDL oxidation are mentioned. It is concluded that lipophilic antioxidants, which can incorporate into LDL with their antioxidative functionalities being exposed ahead of the bis-allylic sites of PUFA in LDL, are most favorable. Besides NZW and WHHL rabbits, apoE deficient mice represent a new pathological animal model for human atherogenesis. This mouse model is also suitable for pharmacological evaluation of antioxidants as antiatherosclerotic agents. The potential of dietary antioxidants in the prevention of CHD is also briefly discussed. |
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