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題名 | 探討Maduramicin Ammonium對紐西蘭白兔腸型球蟲症藥效=Anticoccidal Activity of Maduramicin Ammonium in New Zealand White Rabbit with Intestinal Coccidiosis |
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作者 | 何素鵬; 何麗玲; 董光中; 王渭賢; | 書刊名 | 臺灣畜牧獸醫學會會報 |
卷期 | 67:3/4 民86.12 |
頁次 | 頁151-159 |
分類號 | 437.247 |
關鍵詞 | 紐西蘭白兔; 攜帶離子型球蟲藥; 球蟲症; Maduramicin; Rabbit; Ionophorous anticoccidals; Coccidiosis; |
語文 | 中文(Chinese) |
中文摘要 | 本研究進行攜帶離子型球蟲藥maduramicin ammonium(Cygro)對紐西蘭白兔 (Orycytolagus cuniculus) 感染混合腸型球蟲 (Eimeria spp) 之效果試驗,各給藥組 (劑 量分別為 0.125、0.25、0.375mg/kg bw/day) 於接種前三天開始投藥, 而各接種組每隻兔 子經口感染混合兔腸型球蟲 (E.intestinalis, E perforans, E. magna, E. media) 芽孢 化卵囊 7.5x10 �穩荂A接種後持續投藥 14 天,依各組兔隻每克糞材中卵囊排出量 (OPG)、 增重、飼料效率、腸病變指數及死亡率,評估 maduramicin ammonium 抗兔腸型球蟲症效果 。結果得出,未給藥未接種組 (對照組 ) 兔隻 2 週平均增重 310 g,飼料效率扁 2.0,最 高 OPG 平均值為 1x10 �獺A腸病變指數 1.4,未給藥接種組兔隻平均體重 2 週下降 34g, 接種後最高 OPG 平均值為 1.5x10 �間A 腸病變指數高達 14.6, 死亡率為 40%。 給藥 0.125mg/kg bw/day 接種組,最高 OPG 平均值為 1.2 X10 �獺A腸病變指數 3.2; 與對照組 比較,兔子的增重減少 25%,飼料效率減少 37.8% (P<0.05)。 0.25mg/kgbw/day 接種組, 最高 OPG 平均值 1.3x10 �捸A 腸病變指數 0,兔子的增重及飼料效率與對照紐比較,差異 不顯著。0.75mg/kg bw/day 接種組,最高 OPG 平均值為 5x10 �纂A腸病變指數 2.6,與對 照組比較,兔子的增重減少 37.5%(P<0.05),飼料效率減少 58.2%(P<0.01)。上述的結果顯 示,0.125mg/kg bw/day maduramicin amnonium 未達到良好的抗球蟲效果,而 0.375mg/kg bw/day 組兔子生長不佳可歸因於藥物的毒性作用,所以 0.25mg/kgbw/day( 相當 5 ppm 飼 料添加 ) 為安全且有效的兔腸型球蟲症治療劑量。 |
英文摘要 | Anticoccidal activity of ionophorous antibiotics maduramicin ammonium (Cygro) was studied for New Zealand white rabbit (0rycytolagus cuniculus) infected with Emeria spp. The trial was performed by first giving each rabbit in the medicated group maduramicin (0.125, 0.25, 0.375 mg/kg bw/day, respectively) for 3 days followed by challenging orally with 7.5 x 10 �� sporulated oocysts of rabbit intestinal coccidia (E. perforans, E. media, E. intestinalis, E. magna) and continuously treating with the drug for 2 weeks. Anticoccidal activity was evaluated by weight gain, feed conversion ratio, oocyst per gram feces (OPG), lesion score of intestine and mortality. For the unmedicated-unchallenged group (control group).The average weight gain was 310 g in 2 weeks, feed conversion ratio was 2.0, the average of peak OPG was 1x10 �� and lesion score was 1.4 For the unmedicated-challenged group. The average body weight decreased 34 g in 2 weeks, the average of peak OPG was 1.5x10 ��, lesion score increased to 14.6, and mortality was 40% For the rabbit medicated at 0.125 mg/kg bw/day with challenge (lesion score = 3.2), the average of peak OPG was 1.2x10 ��. The weight gain decreased 25% and feed conversion decreased 37.8% (p<0.05) as compared with those of control group. However, no significant difference in weight gain, and feed conversion ratio was observed in challenged animals treated with maduramicin at 0.25 mg/kg bw/day when compared with control group. The average of peak OPG of this 0.25 mg/kg bw/day treated group (lesion score = 0) was 8.2 x l0 ��. The lesion score was 2.6 for 0.375 mg/kg bw/day medicated-challenged group with the average of peak OPG of 1.2x10 ��. As compared to control group, significant lowering of the weight gain,which decreased 37.5% (p<0.05) and feed which conversion, decreased 58.2% (p<0.05) was observed. Therefore, maduramicin at 0.25 mg/kg bw/day (about 5 ppm in feed) was safe and effective against rabbit intestinal coccidiosis while 0.125 mg/kg bw/day maduramicin ammonium had incomplete protection against Emeria spp and growth performance was depressed at a dose of 0.375 mg/kg bw/day due to toxicity. |
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