頁籤選單縮合
題名 | Maduramicin Ammonium(Cygro)對紐西蘭白兔之毒性試驗=Toxicity of Maduramicin Ammonium (CYGRO) in New Zealand White Rabbits |
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作者 | 何麗玲; 何素鵬; 王渭賢; | 書刊名 | 臺灣畜牧獸醫學會會報 |
卷期 | 67:2 1997.06[民86.06] |
頁次 | 頁87-92 |
分類號 | 437.23 |
關鍵詞 | 紐西蘭白兔; 抗球蟲藥; 毒性; New Zealand white rabbit; Maduramicin ammonium; Anticoccicidal; Toxicity; |
語文 | 中文(Chinese) |
中文摘要 | 本研究探討攜帶離子型抗球蟲藥maduramicin ammonium對紐西蘭白兔 (Orycotolagus cuniculus) 口服毒性。 將 5 週齡的雌性紐西蘭白兔分成 5 組每組五隻, 分別為對照組, 及 0.25、0.375、0.5、0.625 mg/kg bw/day 投藥組, 連續口服給予藥物 30 天以觀察其對兔子的影響。 實驗結束時將兔子犧牲,取其臟器作組織切片,抽血測定血 液生化值。實驗結果得知,在 0.5、0.625mg/kg bw/day 兩組中,血清麩胺酸草酸醋酸轉胺 酵素 (AST)、乳酸脫氫酵素 (LDH) 以及肌酸肌酵素 (CK) 均顯著升高; 給藥各組動物飼料 消耗, 增重及飼料效率的變化和對照組比較,顯示 0.25 mg/kg bw/day 組,飼料消耗增加 2%, 增重增加 6%, 飼料效率增加 5%, 而隨著藥物濃度的增加, 0.375、 0.5 及 0.625 mg/kg bw/day 各組, 其飼料消耗皆別減少 5.9% (P<0.05)、 9.7%(P<0.01) 及 6.4% (P<0.01);增重量則分別減少 31% (P<0.1)、45% (P<0.01) 以及 44% (P<0.01);飼料效率 分別減少 27% (P<0.05)、39% (P<0.01) 及 41% (P<0.01);在組織病變方面,0.375 mg/kg bw/day 組其肝細胞呈現脂肪變性,在 0.5 及 0.625 mg/kg bw/day 二組,其肝細胞及股直 肌雷胞呈現明顯的變性變化。在死亡率方面,0.375 及 0.5 mg/kg bw/day 二組皆為 20%, 0.625 mg/kg bw/day 組之死亡率為 60%。 綜合以上統計分析結果得知, maduramicin ammonium 對紐西蘭白兔的無作用劑量為 0.25mg/kg bw/day。 |
英文摘要 | The experiment was conducted to evaluate the maduramicin toxicity for the New Zealand white rabbits (Orycotolagus cuniculus), in which each group comprised five, 5-week-old female rabbits. Maduramicin ammonium was continuously medicated at the use level of 0.25, 0.375, 0.5 and 0.625 mg/kg bw/day in feed for 30 days. In order to determine the toxic effects of maduramicin ammonium by evaluation feed consumption, weight gain, feed conversion ratio, blood chemistry, histopathology and mortality. the results of blood chemistry revealed that the aspartate transaminase (AST), lactose dehydrogenase (LDH) and creatine kinase (CK) were elevated in rabbits medicated at 0.5 and 0.625 mg/kg bw/day in comparison with referral control values. Comparing with unmedicated group, the feed consumption, weight gain and feed conversion of rabbits treated with 0.25 mg/kg bw/day maduramicin were observed to increase aproximately 2%, 6% and 5%. With increasing dosages, at 0.375, 0.5 and 0.625 mg/kg bw/day respectively, feed consumption were decreased 5.9% (P<0.05), 9.7% (P<0.01 and 6.4% (P<0.01), weight gains were decreased 31% (P<0.1), 45% (P<0.01) and 41% (P<0.01), feed conversion rations were decreased 27% (P<0.05) , 39 (P<0.01) and 41% (P<0.01). In histopathology, the results at 0.375 mg/kg bw/day revealed the fatty change in the liver cells and 0.5, 0.625 mg/kg bw/day caused a significant cell degeneration in the liver and muscle of thigh. Mortalities of rabbits treated with 0.375 and 0.5 mg/kg bw/day were 20%, and 0.625 mg/kg bw/day was 60%. These data indicated that the maduramicin ammonium at 0.25 mg/kg bw/day was no observed effect level for the New Zealand white rabbits. |
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