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題名 | 迷走神經在針刺足三里穴對心臟血管系統效應所扮演的角色=The Role of Vagus Nerve in Acupuncture Stimulation of Zu-San-Li Acupoint on Cardiovascular System |
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作者 | 陳必誠; 謝慶良; 林昭庚; | 書刊名 | 中國醫藥學院雜誌 |
卷期 | 6:3 1997.12[民86.12] |
頁次 | 頁211-220 |
分類號 | 413.91 |
關鍵詞 | 迷走神經; 不同頻率電針; 心搏速率; 收縮壓; 舒張壓; 平均動脈壓; Zusanli(ST-36); Electro-acupuncture; Blood pressure; Heart rate; Vagus nerve; |
語文 | 中文(Chinese) |
中文摘要 | 為了研究針刺的生理機轉,及迷走神經在不同頻率電針刺激所引發心臟血管系統 效應中所扮演的角色, 我們將 18 隻 S.D. 老鼠在使用 Urethane(2ml/kg) 麻醉下, 使用 PE50 導管分別插入它們的右側股動脈和股靜脈, 然後將動脈導管的另一端連接於多頻道記 錄器上,分別記錄它們的心搏速率、收縮壓、舒張壓和平均動脈壓。 它們被分成 2Hz 電針 、15Hz 電針和 100Hz 電針刺激組, 每組 6 隻。它們的左側的足三里穴被研究。實驗過程 分成電針刺激前期、電針刺激期、迷走神經截斷期和電針刺激中止期,每期均為十五分鐘。 我們的結果是 2Hz 電針刺激不能改變心搏速率, 但當兩側迷走神經被截斷後則心搏速率增 加,這種心搏速率的增加隨著電針刺激中止而稍微減少。 15Hz 電針刺激增加心搏速率,而 這種心搏速率的增加不因迷走神經的截斷或刺激中止而有所改變。100Hz 電針刺則對心搏速 率沒有影響。至於血壓方面,2Hz 電針刺激導致收縮性、舒張性和平均動脈壓下降,但這種 下降不因迷走神經的截斷而有所改變。 15Hz 和 100Hz 電針刺激對於血壓的效應則部份與 2Hz 電針刺激相同。我們的結論是 2Hz、15Hz 和 100Hz 的電針刺激左足三里穴,它們對心 搏速率以及心收縮壓、舒張壓以及平均動脈壓有不同的效應。迷失神經對針刺所引發的心搏 速率變化貢獻了部份影響,而扮演著重要的角色,但對血壓的影響似乎非常的微弱。血壓的 影響是一個極為複雜的因素,電針刺激對血壓的影響可能關係到針刺所引發的中樞神經系統 效應, 我們推測與內嗎啡以及 Serotonin 的釋放有關, 它們的傳入路徑可能經由 ergoreceptors 的小徑有髓神經纖維( Group III )。 |
英文摘要 | The purpose of this study is to examine the effect of acupuncture on cardiovascular system and the role of vagus nerve in the mechanism of this phenomenon. In the present study. 18 S.D. strain rats each weighing 250-350gm. were anesthetized by intra-periti on eal injection of Urethane. PE50 trbe were inserted into their right femoral arteries and veins, and connected to the polygraph recorder to measure the wchanges rate and blood pressure. Rats were divided into three main groups(2Hz, 15Hz and 100 Hz.)each of them containing 6 animals. Vagotomy and electroacupuncture on the left Zusanli(ST-36)acupoint were performed. The exper imental process included 4 differnet stages each of them lasted for 15 minutes:pre-electro-acupunctured, electro-acupunctured, vagotomy and ost-electro-acupuncture stage. The results demonstrated that 2 Hz electro-acupuncture exerted no effect on heart rate. Although elevation of heart rate occurred following vagotomy, it declinedgradually after the cessation of electro-acupuncture. On the other hand, 15 Hz electro-acupuncture induced elevatio of heart rate which persisted after vagotomy or the cessation of electro-acupuncture: whilst100Hz electro-acupuncture exerted no effect on heart rate. In addition, the results showed that 2Hz electro-acupuncture caused a reduction in the systolic, diastolic and mean blood pressure which persisted after vagotomy. Part of the effects on blood pressure induced by 15 Hz and 100Hz electro-acupuncture resembled to those caused by 2Hz electro-acupuncture. We therefor concluded that various effects on heart rate and blood pressure could be induced by applying 2Hz, 15Hz and 100Hz electro-acupuncture on the left Zu-San-Li acupoint. The vagus nerve might play role in the change of blood pressure. The change of blood pressure involves a very complicate mechanism. The change of blood pressure caused by electro-acupuncture may be associated with activation of the central nervous system, and the release of endorphin and serotonin evoked by nacupuncture stimulation as well as their transportation along the afferent pathway from the small myelinated nerve fibers(group III) of the ergo-receptors. |
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