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題 名 | 使用0.05% Isotretinoin gel及0.05% Tretinoin cream治療痤瘡的雙盲試驗比較報告=Double Blind Clinical Trial of 0.05% Isotretinoin Gel and 0.05% Tretinoin Cream for Treatment of Acne |
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作 者 | 王貞乃; 曾興隆; | 書刊名 | 中華皮膚科醫學雜誌 |
卷 期 | 15:4 1997.12[民86.12] |
頁 次 | 頁242-248 |
分類號 | 415.7712 |
關鍵詞 | 痤瘡; Acne; Isotretinoin; Tretinon; Retinoid dermatitis; |
語 文 | 中文(Chinese) |
英文摘要 | 這是一項比較 0.05% Isotretinoin gel (Isotrex) 及 0.05% Tresinoin cream (Retin-A) 對於痤瘡療效及耐受性的雙盲試驗。 從民國 83 年 9 月到 84 年 1 月, 共有 60 人進入此項為期三個月的臨床試驗, 年齡 15 歲到 30 歲,其中 59 人 (Retin-A30 人 及 Isotrex29 人 ) 有完整的資料可供評估。以痤瘡治療後改善的程度而言,二者相近。醫 師及使用者的改善滿意度, 在 " 好及非常好 " 的項次中, 兩種藥物沒有明顯差異 (Rexin-A 的 80% 及 Isotrex 的 79%)。 對於藥物的耐受性,醫師及使用者在 " 好及非常 好 " 的項次中, 二者仍然反應相近 (Retin-A 的 70% 及 Isotrex 的 66% )。 但在 Isotrex 這一組中,約有 10 % 的比率覺得很難忍受, 而 Retin-A 這一組,則無人有此感 覺。 參與者放棄治療的比率上,Isotrex (17%) 也略高於 (Retin-A (13%)。A 酸性皮膚炎 的發生率, Isotrex 的 83% 少於 Retin-A 的 93 %,二者的持續時間皆以 1 至 2 週為最 常見。A 酸性皮膚炎的主要症狀:兩組人員皆以脫皮 (Retin-A 86%,Isotrex 79%) 最常見 ,也多以輕微到中等的程度來表現。值得注意的是 A 酸性皮膚炎的復發率,Isotrex (33%) 明顯少於 Retin-A (60%)。本臨床實驗證實 Isotrez 和 Retin-A 在治療痤瘡方面具有相等 效果, 但在藥物副作用方面則各有優劣, 其原因則有待進一步的研究。 (中華皮誌 15:242-248,1997) in the ISOTREX group. In the ISOTREX group, about 10% of patients rated tolerance as poor compared to none from the Retin-A group. The dropout rate for the ISOTREX group at 17% was slightly higher than the Retin-A group at 13%. The incidence of retinoid dermatitis was 83% in the ISOTREX group compared with 93% in the Retin-A group and the symtoms normally lasted for one to two weeks in both treatment groups. The most common symptom experienced by patients in both groups was scaling, and severity ranged from mild to moderate. This was reported by 86% of patients in the Retin-a group and 79% of patients in the ISOTREX group. The recurrence rate of retinoid dermatitis in the ISOTREX group at 33% was much lower compared to 60% in the Retin-A group. The results of this study comfirmed that both ISOTREX group and Retin-A were equally effective in the treatment of acne. However, the tolerance of individual symptoms by the patients in the two treatment groups variess and this needs to be further investigated. (Dermatol Sinica 15: 242-248,1997) |
本系統中英文摘要資訊取自各篇刊載內容。