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題名 | 以藍光療法治療痤瘡=Blue Light Phototherapy in the Treatment of Acne |
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作 者 | 吳冠興; 許義郎; 宗天一; | 書刊名 | 中華皮膚科醫學雜誌 |
卷期 | 21:3 2003.09[民92.09] |
頁次 | 頁246-254 |
分類號 | 415.7712 |
關鍵詞 | 藍光; 痤瘡; Blue light; Acne vulgaris; Fluorescence; Propionibacterium acnes; |
語文 | 中文(Chinese) |
中文摘要 | 近幾年六,有越來越多的證據顯示,藍光對痤瘡是一種有效的治療方式。吾人收集31 位輕度至中重度臉部痤瘡患者,採用前瞻性單盲試驗,評估藍光對痤瘡的療效,並依病患特徵如:性別,疤痕有無,毛孔大小及病灶分佈狀態,分析其是否可用來預測療效。此外,吾人亦記錄治療前後病灶燭光強度。結果顯示:經過每週兩次,連續四週的藍光照射,治療成功率達71%。而且,四次照射後的反應,可拿來做為病患是否適合此治療方式的指標(靈敏度85%,陰性預測值73%)。至於性別,疤痕有無,毛孔粗大與否並無法作為預測療效的依據(P值依次為.318,.466和.454)。然而,治療前的燭光強度( P= .301)或治療前後燭光強競的改變( P= .589)與療效並無關連,這間接暗示藍光對痤瘡有療效,除了藉由殺死痤瘡初油酸菌外,似乎存有其他未知的作用機轉。(中華皮誌21:246-254, 2003) |
英文摘要 | In the past few years, more and more evidence has shown that blue light irradiation is effective against acne. To evaluate blue light phototherapy in the treatment of acne, we designed a prospective and investigator-masked study and 31 patients with mild to moderately severe acne vulgaris on their face were enrolled. Patients’ characteristics, including gender, scarring, pore size and acne distribution, were documented to determine if they could be used as predictive factors of therapeutic effectiveness. Besides, pretreatment fluorescence intensity and intensity change after treatment were documented. Our study showed: 71% patients improved after blue light irradiation twice weekly for four consecu- tive weeks. Besides, responsiveness after 4 sessions of irradiation can be used as a reference to judge if the patient is a good candidate for phototherapy (85% sensitivity and 73% NPV). Gender, scarring and pore size cannot be used as predictive factors of therapeutic effectiveness ( P=.318, .466 and .454, respectively). There was no correlation between pretreatment fluorescence intensity and therapeutic effectiveness ( P=.301). Moreover, therapeutic effectiveness was not related to fluorescence intensity change ( P=.589). These two findings suggested that blue light has as yet nknown effects in acne treatment in additional to destruction of Propionibacterium acnes. (Dermatol Sinica 21:246-254, 2003) |
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