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| 題 名 | 以不同比例的PLLA/PEG研製微小球及其包覆藥物的釋放評估=The Effects of Different Properties of PLLA/PEG Microspheres on Drug Release |
|---|---|
| 作 者 | 鍾次文; 黃義侑; 曾增文; | 書刊名 | 中華醫學工程學刊 |
| 卷 期 | 17:4 1997.12[民86.12] |
| 頁 次 | 頁257-263 |
| 分類號 | 418.43 |
| 關鍵詞 | 生物降解性聚合物; 藥物釋放; 微小球; Biodegradable polymers; PLLA/PEG; Drug release; Microencapsulation; |
| 語 文 | 中文(Chinese) |
| 中文摘要 | 本研究以共沈澱法( coaceration technique ), 溶劑揮發法( solvent evaporation )或乳化法( emulsion )將 lidocaine,gentamicin 和 pilocarpine 等藥 物載入具有生物降解性的聚孔酸與聚乙二醇共聚物( PLLA/PEG copolymer )的微小球中。 並針對以不同比例的 PLLA/PEG 及不同的製備方法所研製之微小球與包覆技術對微小球的顆 粒大小、表面結構特性、和體外藥物釋放特性等的影響進行探討。 實驗結果顯示加入親水性的聚乙二醇( Poly ( ethylene glycol )鏈段之聚乳酸與聚乙 二醇共醇聚合物,其結構較聚乳酸均聚物鬆散,製成之微小球的顆粒小,表面黏滯、不如均 聚物光滑,在體外藥物釋放測試中,藥物溶離釋出的速度快。 |
| 英文摘要 | Lidocaine, gentamicin, or pilocarpine were loaded into biodegradable PLLA or PLLA/PEG microspheres by the methods of coacervation, solvent evaporation and emulsion. The effects of drug properties, particle size, drug loading and method of microencapsulation on the in vitro drug dissolution were investigated. Experimental results showed that the structure of microparticles made up of PLLA/PEG copolymer was not so compact as that made up of PLA homopolymer, and with smaller particle size. PLA/PEG microparticles were not so smoother as that of PLA. Drug release from the microspheres of PLLA/PEG was faster than that in a pure PLA homopolymer. |
本系統中英文摘要資訊取自各篇刊載內容。