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- Genetic Basis of Human Oral Cancer
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頁籤選單縮合
題 名 | Genetic Basis of Human Oral Cancer=人類口腔上皮癌分子機轉之文獻回顧 |
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作 者 | 高壽延; | 書刊名 | 牙醫學雜誌 |
卷 期 | 17:4 1997.12[民86.12] |
頁 次 | 頁227-240 |
分類號 | 416.94 |
關鍵詞 | 口腔上皮癌; 腫瘤基因; 抑制腫瘤基因; Oral cancer; Oncogenes; Tumor suppressor genes; |
語 文 | 英文(English) |
中文摘要 | 癌病目前已知是一種累積了數個突變基因而形成的疾病。有三大類致癌因子可會 導致口腔上皮細胞遺傳基因的突變,造成細胞的惡性轉化,包括了慢性的化學性、物理性刺 激及病毒感染。由於細胞癌化並非一蹴可成,所以目前可依基因之突變數將其過程階段性略 加區分為早期及進行中。而整個癌化過程中最具決定性之兩大類基因,分別為腫瘤基因與抑 制腫瘤基因。人類口腔上皮癌形成過程中相關之此二類基因,近年來雖已逐漸被發現,但其 完整的致病機轉仍有待探討。本文就近年來人類口腔上皮癌之分子生物學研究文獻作一整理 及回顧。 |
英文摘要 | Cancer is considered to be a multi-hit process which involves a number of aberrant genetic events culminating in malignant transformation. Three major known carcinogenic stimuli in the oral cavity include the chemical, physical (radiation), and infectious (virus) agents that can cause point mutation, deletion, insertion, or translocation of genetic elements. The process of malignant transformation may be divided into stages of initiation and progression of the disease, in which a number of discordant genetic events occur. The multi-step carcinogenesis mainly includes the aberrant expression of two interacting classes of genes, namely oncogenes and tumor suppressor genes. In squamous cell carcinoma (SCC) of the head and neck, the role of both oncogenes and tumor suppressor genes has been identified during the course of the disease. Although there has been much progress in the study of oncogenesis in oral cancer, multiple leads remain to be explored. Future studies may provide clues to early diagnosis of oral malignancy and improve prognostics. The ultimate goal is the development of treatment modalities that can provide curative outcomes for this disease. |
本系統中英文摘要資訊取自各篇刊載內容。