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題名 | Expression of Epidermal Growth Factor Receptors and C-ErbB-2 Proteins in Human Astrocytic Tumors=上皮生長激素受器和C-erbB-2蛋白在人類星狀細胞瘤的表現 |
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作者姓名(中文) | 黃旭霖; 蔡志仁; 林相如; 洪純隆; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷期 | 13:7 1997.07[民86.07] |
頁次 | 頁417-424 |
分類號 | 415.138 |
關鍵詞 | 上皮生長激素受器; C-erbB-2蛋白; 星狀細胞瘤; Epidermal growth factor receptor; C-erbB-2 protein; Astrocytoma; |
語文 | 英文(English) |
中文摘要 | 基因結構或功能的改變和腫瘤的生成有非常密切的關連。人類腦腫瘤中,各種致癌基因的研究報告相當多,尤其是上皮生長激素受器更是詳盡,然而 c-erbB-2 蛋白在星狀細胞瘤中的研究則顯得相對稀少。由於上皮生長激素受器和 c-erbB-2 蛋白結構類似,但免疫性不同,因此,本研究利用免疫組織染色方法,分析 33 例人類星狀狀細胞瘤中上皮生長激素受器和 c-erbB-2 蛋白的表現。根據世界衛生組織腦腫瘤分類,本研究包括 9 例低惡性度星狀細胞瘤, 15 例分化不良星狀細胞瘤和 9 例多形性神經膠母細胞瘤。上皮生長激素受器的表現可在 28 例腫瘤發現,佔 85 %,其中,低惡性度星狀細胞瘤 6 例(67 % ) ,分化不良星狀細胞瘤有 13 例 (87 %) ,而最惡性的神經膠母細胞瘤有 9 例 (100 % )。 c- erbB-2 蛋白可在17例星狀細胞瘤發現,佔 51.5 % ,包括 3 例低惡性度星狀細胞瘤(37.5 %) , 9 例分化不良星狀組飽瘤(81.5 %) , 和 5 例神經膠母細胞瘤(62.5 %)。研究結果顯示,上皮生長激素受器的表現,隨著星狀細胞瘤惡性度增加而增強,。c-erbB-2蛋白的表現,雖無此趨向,但在較惡性的分化不良星狀細胞瘤和神經膠母細胞瘤中,有較高比例的表現。 |
英文摘要 | Tumorigenesis is the result of sequential or multiple genetic alterations. The• over- expression or amplification of various oncogenes in. diverse human brain tumors have been observed. While numerous studies on the immunohistochemical demonstration of EGFR-overexpression have been reported, little has been found in the literature about the c-erbB-2 protein in human astrocytic tumors. In the present study, we evaluated the expression of EGFR and c-erbB-2 protein in 33 astrocytic tumors with immunohistochemistry. According to the World Health Organization brain tumor classification, the study included 9 low-grade astrocytomas (grade 2), 15 anaplastic astrocytomas (grade 3), and 9 glioblastomas multiforme (grade 4). The positive EGFR immunoreactivity was detected in 28 (85%) of 33 tumors. The expression of EGFR increased with the grade of malignancy in low-grade astrocytomas (67%), anaplastic astrocytomas (87%), and glioblastomas (100%). For the expression of c-erbB-2 protein, 17 (51.5%) of 33 tumors were positive immunostain, including 3 low-grade astrocytomas (37.5%), 9 anaplastic astrocytomas (81.8%), and 5 glioblastomas (62.5%). Different degrees of immunoreactivity for c-erbB-2 protein were found in variant grades of astrocytomas. However, the positive immunostain of EGFR displayed moderate or strong reactivity. The coexpression of EGFR and c-erbB-2 protein was found in 17 (15.5%) of 33 tumors. The results emphasize that the overexpression of EGFR parallels astrocytoma progession and higher frequency of c-erbB-2 immunoreactivity was seen in snaplastic astrocytomas and glioblastomas than in low-grade astrocytomas. |
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