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題名 | Clinical Significance of Distribution Patterns of p53 Immunoreactivity in Astrocytic Tumors=p53免疫組織染色型態應用於星狀細胞瘤的臨床意義 |
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作者姓名(中文) | 黃旭霖; 洪義人; 劉安祥; 李昆興; 林靖國; 思瑋玓; 蔡志仁; 林相如; 黃祖源; 洪純隆; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷期 | 16:6 2000.06[民89.06] |
頁次 | 頁279-284 |
分類號 | 415.138 |
關鍵詞 | p53免疫組織染色; 星狀細胞瘤; p53; Immunoreactivity; Astrocytoma; Prognosis; |
語文 | 英文(English) |
中文摘要 | 同級惡性度星狀細胞瘤患者的預後不同,顯示此腫瘤的生物特性因各 個腫瘤而異。p53免疫組織染色和腫瘤患者的預後,兩者關係目前仍未釐清。本 研究從p53染色型態的觀點分析各級惡性度星狀細胞瘤患者的預後與p53染色型 態的關係。p53免疫染色可分為四種型態:陰性,散落性(scattered),局部群集性 (focally clustered),廣泛群集性(diffusely clustered)。再依型態特性及陽性細胞數 有意義比率(大於或等於5%)可分為二大類:p53陽性染色(局部和廣泛群集性)及 p53陰性染色(陰性及散落性)。研究顯示在WHO分類的各級惡性度星狀細胞瘤 患者的預後和p53染色型態呈有意義的差別(p=0.0185)。因此,我們認為p53免 疫染色型態可作為同級惡性度星狀細胞瘤患者預後之參考指標。 |
英文摘要 | The difference of prognosis in patients with the same WHO grade of astrocytic tumors suggests that such tumors comprise a heterogeneous group in biological behavior. The correlation between p53 immunoreactivity and prognosis has often been reported but remains controversial. From the perspective of clonal expansion of p53 immunopositive cells, the distribution patterns of p53 immunoreactivity can be divided into four types: negative, scattered, focally clustered, and diffusely clustered. The survival rate was evaluated by classifying the p53 immunoreactivity into two groups: the significantly immunopositive patterns (focally and diffusely clustered types) and the significantly immunonegative patterns (negative and scattered types). The survival analysis showed a highly significant difference between these two patterns within the same WHO grade of astrocytic tumors (p=0.0185). Our studies demonstrate that the distribution patterns of p53 immunoreactivity, which reflect the trends of clonal expansion of p53 immunopositive cells, are significantly valuable in predicting the prognosis of patients with the same WHO grade of astrocytic tumors. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。