頁籤選單縮合
| 題 名 | 應用呼出氣體濃度檢測四氯乙烯之體內劑量及暴露值=Breath Smpling as an Indicator of Internal Dose after Tetrachloroethylene Exposure |
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| 作 者 | 錢葉忠; | 書刊名 | 中華職業醫學雜誌 |
| 卷 期 | 4:3 1997.07[民86.07] |
| 頁 次 | 頁133-140 |
| 分類號 | 412.78 |
| 關鍵詞 | 呼出氣體濃度; 檢測; 四氯乙烯; 體內劑量; 暴露值; |
| 語 文 | 中文(Chinese) |
| 中文摘要 | 本研究利用現場及控制暴露實驗研究人體對於四氯乙烯暴露中及暴露後的吸收及 排除動力學。這項研究藉同步測量短時間空氣及呼出氣體濃度,以了解人體對於暴露濃度改 變之反應,並用於估算吸收劑量。在現場暴露期間,呼出氣體濃度之改變,緊密反映出現場 空氣濃度之變化。 吸收劑量與暴露值呈現很高的直線關係 (r �� =.99, p<.05)。暴露後之 呼出氣體濃度大致反映出吸收 (體內 ) 劑量, 但此濃度,特別是暴露剛結束時,則受到暴 露時間長短之影響。當暴露時間較短時,較高比例之吸收劑量將會於暴露後迅速被呼出。而 由控制暴露實驗結果顯示,在相同之總暴露下,較短之暴露時間也導致較大之吸收劑量及在 暴露後的數小時內較高比例之吸收劑量的呼出。這些結果顯示,暴露後之呼出氣體濃度雖可 用於評估環境和職業暴露及呼收劑量, 但它受到暴露時間 (或暴露濃度 ) 之影響,因此當 運用呼出氣體以評估暴露值及體內劑量時,實際之暴露時間須加以考慮。 |
| 英文摘要 | Body absorption and elimination kinetics during and after tetrachloroethylene exposures were examined from a field and a controlled exposure study using exhaled breath analysis. Short-term exposure air and alveolar breath samples were collected simultaneously to investigate the body's response to environmental changes and to estimate absorbed (internal) dose. A single subject was used throughout the study to eliminate inter-individual variability. During the exposure, the changes of breath concentration closely reflect the changes of air concentration. Absorbed (internal) doses are highly (r �� =.99, P<.05) correlated with total exposrues. Postexposure breath conentrations in general reflect internal dose but are affected by exposure duration, especially during the early elimination phase. Higher percentage of the absorbed Perc was expired shortly following exposure when exposure duration was shorter. The results of controlled exposure study also showed that, for the same total exposures, shorter exposure resulted in statistically significantly higer (p<.05) internal dose and higher percent dose expired, during the first postexposure hours. These findings suggested that postexposure breath concentrations, though are useful in assessing the internal dose attributed to environmental Perc exposures, are a function of exposure duration or exposure concentration. Therefore, exposure duration should be determined if postexposure breath concentrations are to be used to estimate internal dose or past exposures. The field exposure measurement also suggest a need to shorten the stay in commercial laundromats with dry-cleaning operation to minimize the Perc exposure at low-ppm levels. |
本系統中英文摘要資訊取自各篇刊載內容。