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題名 | β-胡蘿蔔素在有或無膽固醇攝取下對大白鼠脂質代謝的影響=Effects of β-Carotene on Lipid Metabolism in Rats Fed with or without Cholesterol |
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作 者 | 施純光; 鄭心嫻; 謝明哲; | 書刊名 | 中華民國營養學會雜誌 |
卷期 | 22:3 1997.08[民86.08] |
頁次 | 頁287-301 |
分類號 | 411.38 |
關鍵詞 | β-胡蘿蔔素; 膽固醇; 大白鼠; 脂質代謝; β-carotene; Cholesterol; Rats; Lipid metabolism; |
語文 | 中文(Chinese) |
中文摘要 | 本研究之目的是探討β-胡蘿蔔素在有或無膽固醇攝取下對大白鼠脂質代謝的影響。將40隻Wistar品系雄性大白鼠(重約250g)隨機分成4組,以1%膽固醇的給予或不給予,及0.2%β-胡蘿蔔素的給予或不給予,作2X2 factorial 實驗設計。各組均於第3週及第6週分別宰殺半數大白鼠,分析其血清及肝臟中總膽固醇(TC)、三酸甘油酯(TG)濃度,血清並分析其中高密度脂蛋白膽固醇(HDL-C)及低密度脂蛋白膽固醇(LDL-C)濃度,此外利用HPLC分析血清及肝臟中視網醇及β-胡蘿蔔素濃度。實驗結果顯示,當飼料中添加膽固醇時,在第3週即造成肝臟TC濃度顯著升高,血清TC濃度則在第6週時上升,且以未添加β-胡蘿蔔素之膽固醇組上升最高。第3週時與無膽固醇組相比,膽固醇組之血清HDL-C濃度較低,而LDL-C濃度無顯著差異;第6週時,未添加β-胡蘿蔔素之膽固醇組則無此現象,且HDL-C濃度顯著上升。膽固醇的給予使肝臟TG在第3週時即顯著升高,血清TG濃度則無論在第3週或第6週時均與無膽固醇組間無顯著差異;β-胡蘿蔔素的給予在第3週時使肝臟TG濃度降低,並使血清TG濃度升高,在第6週時則與未給予β-胡蘿蔔素組間無顯著差異。攝取膽固醇使肝臟視網醇濃度下降,攝取β-胡蘿蔔素則使肝臟視網醇濃度上升,但不影響血清視網醇濃度。血清β-胡蘿蔔素濃度因膽固醇之攝取而下降,肝臟β-胡蘿蔔素濃度則不受膽固醇攝取之影響。 |
英文摘要 | The purpose of this study was to investigate the effect ofβ-carotene on lipid metabolism in rats fed with or without cholesterol. Forty male adult Wistar rats were randomly divided into four groups in a 2X2 factorial design according to 1% cholesterol (with or without) and 0.2% β-carotene (with or without). Half of rats of each group were dilled after three- or six-week feeding, then liver and artery blood were collected. Items analyzed included serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), liver total cholesterol and liver triglyceride. Retinol and β-carotene in serum and liver were analyzed by HPLC. The results showed that cholesterol-fed groups had significantly higher liver total cholesterol concentrations after three-week feeding and higher serum total cholesterol concentrations after six-week feeding, especially in the non-β-carotene-fed group. Cholesterol-fed groups had lower serum HDL-C concentrations after three-week feeding, but there was no difference in the LDL-C concentration. After six-week feeding, HDL-C concentration was still lower in rats fed cholesterol but no β-carotene whereas LDL-C concentration rose significantly. Rats fed cholesterol and β-carotene had no such condition and the HDL-C concentration rose significantly. Cholesterol feeding made the liver TG concentraton higher after three-week feeding, but there was no difference in the serum TG concentration after either three-or six-seek feeding. β-carotene feeding showed lower liver TG concentration and higher serum TG concentration after three-week feeding, but no difference in serum TG concentration between β-carotene-fed and non-β-carotene-fed groups after six-week feeding. Cholesterol feeding made the liver retinol concentration lower whereas β-carotene feeding made the liver retinol concentration higher but had no effect on the serum retinol concentration. The serum β-carotene concentration was decreased whereas the liver β-carotene concentration was not affected due to cholesterol feeding. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。