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題名 | Compatibility of Ceftizoxime Sodium and Famotidine in 5% Dextrose Injection=Ceftizoxime Sodium及Famotidine於5%葡萄糖靜脈注射輸送液中配伍性之研究 |
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作者姓名(中文) | 王孟廷; 李貫棠; 黃志賢; 王大鵬; | 書刊名 | 醫學研究 |
卷期 | 18:1 1997.07[民86.07] |
頁次 | 頁29-60 |
分類號 | 416.351 |
關鍵詞 | 葡萄糖靜脈注射輸送液; 儲存; 高壓液相層析儀; 配伍性; Ceftizoxime sodium; Famotidine; Dextrose injection; Storage; HPLC; Compatibility; |
語文 | 英文(English) |
中文摘要 | 本研究以高壓液相層析儀進行探討Ceftizoxime及Famotidine於5%葡萄糖靜脈注射輸送液中配伍性,以5%葡萄糖靜脈注射輸送液配製含Cefitizoxime 5 mg/ml及Famotidine 0.2 mg/ml之靜脈注射混合液,分別於4 ℃及25 ℃之不同條件下儲存,於0.25、2、5、10、24、48、96、168及240小時,分別取樣2ml予以測定pH值及外觀之觀察外,同時以發展之HPLC安定性指示分析法對Ceftizoxime及Famotidine分別予以定量。 實驗結果顯示,Ceftizoxime及Famotidine於5%葡萄糖靜脈注射輸送液中,於25 ℃條件下,僅可僅存168小時,然於4 ℃條件下,至少可儲存240小時。 |
英文摘要 | The compatibility of ceftizoxime sodium and famotidine in 5% dextrose injection stored at two temperature was studied. Ceftizoxime sodium and famotidine were reconstituted or diluted with 5% dextrose injection to form an admixture with a famotidine concentration of 0.2 mg/ml and a ceftizoxime concentration 5 mg/ml. The admixture was stored in 100-ml vented i.v. containers in the dark at 4 and 25 ℃; three containers were stored at each temperature. A 2-ml sample was taken from each container after 0.25, 2, 5, 10, 24, 48, 96, 168 and 240 hours of storage and visually inspected, tested for pH, and assayed by a stability-indicating high-performance liquid chromatographic method. Triplicate studies were done for each storage condition. No color change or precipitation was observed in any sample at any time during the study. More than 90% of the initial concentrations of both drugs remained for 240 hours at 4 ℃ but 168 hours at 25 ℃. Under the conditions of this study, ceftizoxime 5 mg/ml and famotidine 0.2 mg/ml in adimixture in 5% dextrose injection are stable for only 168 hours at 25 ℃ and for at least 240 hours at 4 ℃. |
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