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題 名 | Surface Properties of Phospholipids: Pulmonary Surfactant Perspective=磷脂質的表面性質:肺界面活性劑之觀點 |
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作 者 | 徐善慧; | 書刊名 | 界面科學會誌 |
卷 期 | 20:1 1997.04[民86.04] |
頁 次 | 頁1-11 |
分類號 | 361.1924 |
關鍵詞 | 磷脂質; 二軟脂醯卵磷脂; 單分子膜; 表面張力; 相轉變; Phospholipids; Pulmonary surfactant; DPPC monolayers; Surface tension; Phase transition; |
語 文 | 英文(English) |
中文摘要 | 磷脂質的生理意義是雙重的,一方面它是細胞膜的主要成分,因而牽涉到細胞的硬度與訊號轉換等功能;另一方面它也是肺界面活性劑的主成分,使肺泡不塌陷。二軟脂醯卵磷脂是肺界面活性劑中含量最多的磷脂質,它具有能因溫度與表面壓而引起的相轉變,同時它的單分子膜也能承受極高的表面壓,這些都與肺界面活性劑所具有的表面活性有關。但是純二軟脂醯卵磷脂單分子膜在壓縮下會崩潰,且無法藉再擴張而重新分布於界面。所以天然的界面活性劑中必具有某些物質可以幫助擴張時的再分布於界面,且能優先於崩潰時擠出而避免二軟脂醯磷脂分子的散失。這方面的基礎研究雖多,但肺界面活性劑的表面動態性質是如何經由二軟脂醯卵磷脂與其他飽和與不飽和磷脂質和界面蛋白質協調達成,其真正機制尚未確立。至於在臨床應用方面,合成的肺界面活性劑在用於呼吸窘迫的治療時,其再分布性也應注意改善。 |
英文摘要 | The importance of phospholipids in the physiological functions is two-fold, including their roles in the cell membranes and those in the pulmonary surfactant. DPPC, the major component of the pulmonary surfactant, can undergo phase transitions by changing either temperature or pressure. This molecule is responsible for the high surface pressure that can be withstood in monolayers of the pulmonary surfactant. The properties of DPPC may explain the surface activity of natural lung surfactant to some extent. However, DPPC molecules are not readily adsorbed to the air-water interface. In addition, high pressure can force DPPC molecules to be squeezed out from the monolayers, and those molecules lost in the dynamic cycles cannot go back to the film by itself. To sustain the surface tension lowering function of DPPC in the normal lung, adsorption and dynamic respreading of DPPC must be facilitated, and premature exclusion of DPPC must be avoided. These features are likely to be coordinated by other saturated and unsaturated phospholipids as well as surfactant proteins. Much effort has been made in this research area to enucleate the dynamic surface activity of films of pulmonary surfactant, but the true mechanism is still not well defined. In the case of clinical applications, the respreading behavior of artificial surfactant must be improved hence in surfactant therapy for respiratory distress. |
本系統中英文摘要資訊取自各篇刊載內容。