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題名 | Penicillin-Resistant Pneumococcal Infections in Children=兒童之具盤尼西林抗藥性肺炎球菌感染 |
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作者 | 黃富源; 邱南昌; 劉素琴; | 書刊名 | 臺灣醫學會雜誌 |
卷期 | 96:6 1997.06[民86.06] |
頁次 | 頁414-418 |
分類號 | 417.5351 |
關鍵詞 | 兒童; 盤尼西林; 抗藥性肺炎球菌感染; Penicillin-resistant pneumococcus; Streptococcus pneumoniae; Pneumococcal infections; Bacteremia; Meningitis; |
語文 | 英文(English) |
英文摘要 | Penicillin-resistant pneumococcal infections have been reported worldwide, but rarely reported in Taiwan. From 1990 to 1995, the rate of penicillin-resistant Streptococcus pneumoniae (PRSP) infections in our hospital increased from less than 10% during the first 2 years (1990-91) to 45% during the last 2 years (1994-95). From 1990 to 1995, twenty-four patients with systemic pneumococcal infections were diagnosed in the Department of Pediatrics at Mackay Memorial Hospital. Pneumococci were isolated from blood in 20 patients, cerebrospinal fluid in 12 patients, joint fluid in one patient and pleural effusion in one patient. Four patients had underlying diseases, including ileal atresia, Wiskott-Aldrich syndrome, congenital heart disease, and perilmph fistula. Of the 24 isolates of S. pneumoniae, 17 (70.8%) were intermediately penicillin resistant (minimum inhibitory concentrations between 0.1 and 1.0 μ g/mL), and 7 (29.2%) were hight resistant (minimum inhibitory concentrations > 1.0 μ g/mL). Fourteen patients recovered completely, two had minor sequelae, two had major sequelar, and six died. Four of the 12 patients with meningitis died. In this study, both the rate of PRSP as well as the mortality of patients with PRSP meningitis were high, as compared to previous reports. To reduce the mortality and morbidity of systemic pneumococcal infections, the oxacillin disc diffusion test is important in addition to appropriate antibiotic therapy. |
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